A high density of T-cell lymphocytes and Tregs subset correlate to a worse survival in major salivary gland carcinomas.
1/5 보강
Salivary gland carcinomas (SGC) are rare and heterogeneous tumors with limited therapeutic options in advanced stages.
- p-value p = 0.009
- p-value p = 0.046
APA
Anconelli D, Vasuri F, et al. (2026). A high density of T-cell lymphocytes and Tregs subset correlate to a worse survival in major salivary gland carcinomas.. Scientific reports, 16(1). https://doi.org/10.1038/s41598-026-39357-y
MLA
Anconelli D, et al.. "A high density of T-cell lymphocytes and Tregs subset correlate to a worse survival in major salivary gland carcinomas.." Scientific reports, vol. 16, no. 1, 2026.
PMID
41775752 ↗
Abstract 한글 요약
Salivary gland carcinomas (SGC) are rare and heterogeneous tumors with limited therapeutic options in advanced stages. Recent evidence suggests a potential role of the tumor immune microenvironment (TME) in disease progression. This study aimed to investigate the immune profile of SGCs by analyzing tumor-infiltrating lymphocytes (TILs), tumor-associated macrophages (TAMs), and PD-L1 expression, and to assess their correlation with histological grade and clinical outcome. A retrospective analysis was conducted on 103 SGC cases. Immunohistochemistry for CD3, CD4, CD8, CD20, CD56, PD-1, PD-L1, FOXP3, CD68, and CD163 was performed. Digital slide analysis was carried out in intratumoral and peritumoral regions using QuPath software. High intratumoral FOXP3 + Tregs were significantly associated with high-grade tumors and worse progression-free survival (PFS) (p = 0.009). A higher peritumoral CD3 + T cell density correlated with poor prognosis (p = 0.046). Concordance between pathologist assessments and QuPath quantification was moderate to high (Cohen's K = 0.71). In conclusion, intratumoral Tregs and peritumoural T lymphocytes may be used as negative prognostic biomarkers. Future multicentric studies and AI (Artificial Intelligence)-driven analyses could enhance immune characterization and guide immunotherapeutic strategies in SGC.
🏷️ 키워드 / MeSH 📖 같은 키워드 OA만
- Humans
- Salivary Gland Neoplasms
- Male
- Female
- Middle Aged
- Lymphocytes
- Tumor-Infiltrating
- Tumor Microenvironment
- Aged
- Retrospective Studies
- Adult
- T-Lymphocytes
- Regulatory
- Prognosis
- 80 and over
- B7-H1 Antigen
- Biomarkers
- Tumor
- Tumor-Associated Macrophages
- Artificial intelligence
- Immunohistochemistry
- Salivary gland carcinoma
- Tumor microenvironment
🏷️ 같은 키워드 · 무료전문 — 이 논문 MeSH/keyword 기반
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