Radiotherapy combined with immunotherapy achieves clinical complete response in elderly metastatic penile cancer: a case report.
[BACKGROUND] A combination of local and systemic therapies is used to treat inguinal lymph node metastases post-penile cancer surgery.
APA
Huang G, Li Y, et al. (2026). Radiotherapy combined with immunotherapy achieves clinical complete response in elderly metastatic penile cancer: a case report.. Frontiers in immunology, 17, 1783437. https://doi.org/10.3389/fimmu.2026.1783437
MLA
Huang G, et al.. "Radiotherapy combined with immunotherapy achieves clinical complete response in elderly metastatic penile cancer: a case report.." Frontiers in immunology, vol. 17, 2026, pp. 1783437.
PMID
41878439
Abstract
[BACKGROUND] A combination of local and systemic therapies is used to treat inguinal lymph node metastases post-penile cancer surgery. This multimodal approach may include surgery, chemotherapy, radiotherapy, and immunotherapy.
[CASE SUMMARY] We describe an 89-year-old male with a history of penile cancer status post resection, who presented with multiple metastases to the left inguinal lymph nodes confirmed by pathological biopsy. The patient was treated with a combination of radiotherapy and Pembrolizumab. Following this combined modality therapy, he experienced symptomatic relief and achieved a progression-free survival exceeding 38 months.
[CONCLUSION] This case suggests that concurrent radiotherapy plus Pembrolizumab may achieve durable remission in elderly, chemotherapy-intolerant, metastatic PSCC, but verification in more patients is needed.
[CASE SUMMARY] We describe an 89-year-old male with a history of penile cancer status post resection, who presented with multiple metastases to the left inguinal lymph nodes confirmed by pathological biopsy. The patient was treated with a combination of radiotherapy and Pembrolizumab. Following this combined modality therapy, he experienced symptomatic relief and achieved a progression-free survival exceeding 38 months.
[CONCLUSION] This case suggests that concurrent radiotherapy plus Pembrolizumab may achieve durable remission in elderly, chemotherapy-intolerant, metastatic PSCC, but verification in more patients is needed.
MeSH Terms
Humans; Male; Penile Neoplasms; Aged, 80 and over; Lymphatic Metastasis; Antibodies, Monoclonal, Humanized; Treatment Outcome; Immunotherapy; Combined Modality Therapy; Chemoradiotherapy; Antineoplastic Agents, Immunological
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