Intratumoral heterogeneity in microsatellite instability status at single-cell resolution.
1/5 보강
Intratumoral heterogeneity complicates the interpretation of single-test biomarkers.
APA
Anthony H, Seoighe C (2026). Intratumoral heterogeneity in microsatellite instability status at single-cell resolution.. iScience, 29(3), 114860. https://doi.org/10.1016/j.isci.2026.114860
MLA
Anthony H, et al.. "Intratumoral heterogeneity in microsatellite instability status at single-cell resolution.." iScience, vol. 29, no. 3, 2026, pp. 114860.
PMID
41767255 ↗
Abstract 한글 요약
Intratumoral heterogeneity complicates the interpretation of single-test biomarkers. Microsatellite instability (MSI) is one such biomarker, which is used to guide immune checkpoint inhibitor treatment by classifying samples as having high microsatellite instability (MSI-H) or as microsatellite stable (MSS). However, it is unknown whether MSI itself is a heterogeneous phenomenon. To test this, we curated data from several single-cell RNA sequencing studies with clinical MSI status and developed a computational pipeline that quantifies intratumoral heterogeneity in MSI. Out of 49 individuals, 15 showed evidence of divergence in MSI status between clusters of cancer cells, and most had distinct MSI-H and MSS subclones. These results question the use of MSI as a binary biomarker, and we hypothesize that accounting for heterogeneity could improve its use as a predictive biomarker. Further studies are required to determine the frequency of MSI heterogeneity at the population level and whether it can have clinical implications.
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