The correlation between FDG-PET metabolic parameters, PD-L1 expression and p16/HPV status in oropharyngeal cancers.
2/5 보강
TL;DR
Metabolic tumor burden, reflected by PET/CT-derived MTV and TLG, is positively associated with PD-L1 expression and clinical outcomes in OPSCC, suggesting a biologically meaningful link between tumor glycolytic activity and immune checkpoint regulation, particularly in HPV-associated cases.
PICO 자동 추출 (휴리스틱, conf 3/4)
유사 논문P · Population 대상 환자/모집단
60 patients with newly diagnosed OPSCC who underwent baseline 18F-FDG PET/CT were included.
I · Intervention 중재 / 시술
baseline 18F-FDG PET/CT were included
C · Comparison 대조 / 비교
추출되지 않음
O · Outcome 결과 / 결론
These findings suggest a biologically meaningful link between tumor glycolytic activity and immune checkpoint regulation, particularly in HPV-associated cases. PET/CT-based metabolic profiling may serve as a non-invasive tool for risk stratification and immunotherapy planning in OPSCC.
OpenAlex 토픽 ·
Head and Neck Cancer Studies
Cancer Immunotherapy and Biomarkers
Radiomics and Machine Learning in Medical Imaging
Metabolic tumor burden, reflected by PET/CT-derived MTV and TLG, is positively associated with PD-L1 expression and clinical outcomes in OPSCC, suggesting a biologically meaningful link between tumor
APA
Angéla Horváth, Imre Uri, et al. (2026). The correlation between FDG-PET metabolic parameters, PD-L1 expression and p16/HPV status in oropharyngeal cancers.. European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 283(4), 2475-2483. https://doi.org/10.1007/s00405-025-09982-w
MLA
Angéla Horváth, et al.. "The correlation between FDG-PET metabolic parameters, PD-L1 expression and p16/HPV status in oropharyngeal cancers.." European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, vol. 283, no. 4, 2026, pp. 2475-2483.
PMID
41566029 ↗
Abstract 한글 요약
[PURPOSE] Immunotherapy targeting the PD-1/PD-L1 axis has emerged as a promising strategy in oropharyngeal squamous cell carcinoma (OPSCC). However, reliable non-invasive biomarkers to predict immune checkpoint expression and treatment response are still lacking. This study aimed to investigate the relationship between PET/CT-derived metabolic parameters, PD-L1 expression, and p16/HPV status, and their prognostic value in OPSCC.
[METHODS] In this retrospective analysis, 60 patients with newly diagnosed OPSCC who underwent baseline 18F-FDG PET/CT were included. Tumor PD-L1 expression was assessed using both Tumor Proportion Score (TPS) and Combined Positive Score (CPS). Correlations were analyzed between metabolic PET/CT parameters (maximum standardized uptake value [SUVmax], metabolic tumor volume [MTV], and total lesion glycolysis [TLG]) and PD-L1 expression. Correlation analyses, survival outcomes, and response to chemoradiotherapy were evaluated, with subgroup analyses based on p16 and HPV DNA status.
[RESULTS] Significant positive correlations were observed between volumetric PET/CT parameters and PD-L1 expression. In HPV DNA-positive OPSCC, PET/CT-derived volumetric parameters (MTV and TLG) showed positive correlations with PD-L1 expression (TPS: rho = 0.501 and 0.512; CPS >20: rho = 0.441 and 0.491). Higher MTV and TLG were associated with significantly shorter overall survival ( = 0.005 and = 0.001, respectively). Multivariate Cox regression showed the strong prognostic effect of TLG, independent of p16, MTV and even primary tumor stage. Staging MTV was found to be an independent predictor of complete response to chemoradiotherapy ( = 0.026, OR (odds ratio) = 1.08). (No significant correlation was found in the p16-negative subgroup.)
[CONCLUSIONS] Metabolic tumor burden, reflected by PET/CT-derived MTV and TLG, is positively associated with PD-L1 expression and clinical outcomes in OPSCC. These findings suggest a biologically meaningful link between tumor glycolytic activity and immune checkpoint regulation, particularly in HPV-associated cases. PET/CT-based metabolic profiling may serve as a non-invasive tool for risk stratification and immunotherapy planning in OPSCC.
[METHODS] In this retrospective analysis, 60 patients with newly diagnosed OPSCC who underwent baseline 18F-FDG PET/CT were included. Tumor PD-L1 expression was assessed using both Tumor Proportion Score (TPS) and Combined Positive Score (CPS). Correlations were analyzed between metabolic PET/CT parameters (maximum standardized uptake value [SUVmax], metabolic tumor volume [MTV], and total lesion glycolysis [TLG]) and PD-L1 expression. Correlation analyses, survival outcomes, and response to chemoradiotherapy were evaluated, with subgroup analyses based on p16 and HPV DNA status.
[RESULTS] Significant positive correlations were observed between volumetric PET/CT parameters and PD-L1 expression. In HPV DNA-positive OPSCC, PET/CT-derived volumetric parameters (MTV and TLG) showed positive correlations with PD-L1 expression (TPS: rho = 0.501 and 0.512; CPS >20: rho = 0.441 and 0.491). Higher MTV and TLG were associated with significantly shorter overall survival ( = 0.005 and = 0.001, respectively). Multivariate Cox regression showed the strong prognostic effect of TLG, independent of p16, MTV and even primary tumor stage. Staging MTV was found to be an independent predictor of complete response to chemoradiotherapy ( = 0.026, OR (odds ratio) = 1.08). (No significant correlation was found in the p16-negative subgroup.)
[CONCLUSIONS] Metabolic tumor burden, reflected by PET/CT-derived MTV and TLG, is positively associated with PD-L1 expression and clinical outcomes in OPSCC. These findings suggest a biologically meaningful link between tumor glycolytic activity and immune checkpoint regulation, particularly in HPV-associated cases. PET/CT-based metabolic profiling may serve as a non-invasive tool for risk stratification and immunotherapy planning in OPSCC.
🏷️ 키워드 / MeSH 📖 같은 키워드 OA만
같은 제1저자의 인용 많은 논문 (1)
🏷️ 같은 키워드 · 무료전문 — 이 논문 MeSH/keyword 기반
- Contrast-enhanced CT for attenuation correction in ultra-high sensitivity long-axial field-of-view lymphoma PET: amplified quantification problems?
- Predicting PD-L1 expression status in NSCLC using radiomic analysis of 18 F-FDG-PET/CT images.
- Primary squamous cell carcinoma of the prostate with coexisting separate adenocarcinoma: A case report and review of the literature.
- [F]FDG-PET/CT's change in total lesion glycolysis can accurately identify early response upon neoadjuvant immunotherapy prior to curative-intent surgery in cutaneous squamous cell carcinoma; MATISSE trial.
- Case Report: When syphilis imitates cancer: a case of misdiagnosed cutaneous T-cell lymphoma.
- Diagnostic accuracy of FDG-PET-CT to predict axillary lymph node response after neo-adjuvant chemotherapy in lymph node-positive breast cancer patients.