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Phosphorylation of FBXL3 mediates GLDC polyubiquitination to suppress MHC-I expression and promote cancer immune evasion.

3/5 보강

Cell insight 2026 Vol.5(2) p. 100308 cited 1 OA Tryptophan and brain disorders

TL;DR It is reported that GLDC is polyubiquitinated at K636 following EGFR activation, which drives GLDC-dependent transcriptional inhibition of MHC-I genes and induces tumor cells to evade CD8+ T cell-mediated immunosurveillance.

OpenAlex 토픽 · Tryptophan and brain disorders Cancer, Hypoxia, and Metabolism Polyamine Metabolism and Applications

Liu R, Li S

📖 무료 전문 🟢 PMC 전문 PMC12924200 🔓 OA PDF unpaywall · cc-by-nc-nd

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