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Auto-inducible expression of chimeric antigen receptor T cells using the NR4A1 promoter.

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Immunology and cell biology 2026 Vol.104(4) p. 381-395 OA CAR-T cell therapy research

TL;DR These findings establish the NR4A1 promoter as a native, activation‐inducible system to fine‐tune CAR expression, while maintaining therapeutic efficacy comparable to constitutively expressed CAR T cells.

OpenAlex 토픽 · CAR-T cell therapy research Nuclear Receptors and Signaling Immune Cell Function and Interaction

Smith-Bell SW, Halpin JC, Darcy PK, Liyanage T, Dobson LJ, McLellan AD

📖 무료 전문 🟢 PMC 전문 PMC13071125 🔓 OA PDF unpaywall · cc-by

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