A nature-inspired nanoplatform for multi-protein targeted degradation via the autophagy-lysosome pathway.
2/5 보강
OpenAlex 토픽 ·
Autophagy in Disease and Therapy
Protein Degradation and Inhibitors
Click Chemistry and Applications
Extracellular vesicles (EVs) have emerged as key mediators of intercellular communication.
APA
Bide Tong, Yulei Wang, et al. (2026). A nature-inspired nanoplatform for multi-protein targeted degradation via the autophagy-lysosome pathway.. Cell chemical biology, 33(4), 523-537.e7. https://doi.org/10.1016/j.chembiol.2026.03.007
MLA
Bide Tong, et al.. "A nature-inspired nanoplatform for multi-protein targeted degradation via the autophagy-lysosome pathway.." Cell chemical biology, vol. 33, no. 4, 2026, pp. 523-537.e7.
PMID
41932333 ↗
Abstract 한글 요약
Extracellular vesicles (EVs) have emerged as key mediators of intercellular communication. However, the mechanisms governing their degradation remain poorly understood. In this study, we demonstrated that EVs are predominantly degraded via the lysosomal pathway. Mechanistically, MAP1LC3B recognizes SNX18 on the surface of endosome-escaped EVs to facilitate their sorting into the autolysosomal pathway for degradation. Leveraging this mechanism, we optimized the lysosomal sorting efficiency of EVs by surface display of LIR motifs and constructed an EV-based targeted protein degradation nanoplatform. The EV-based nanoplatform is highly modular and can be combined with monoclonal antibodies in a plug-and-play manner. It demonstrated remarkable efficiency and selectivity in degrading EGFR, PD-L1, and VEGF. Moreover, the nanoplatform demonstrated multi-targeting capability by simultaneously degrading EGFR and VEGF. Our findings uncover a previously unrecognized mechanism of EVs degradation and provide a novel strategy to harness the EVs degradation machinery as a nature-inspired nanoplatform for the degradation of multiple targeted proteins.
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