Association of Basal Thyroid Function with Clinical Outcomes in Patients with Recurrent or Metastatic Nasopharyngeal Carcinoma Treated with PD-L1 Inhibitor KL-A167: A Multicenter Post-hoc Analysis.
2/5 보강
OpenAlex 토픽 ·
Head and Neck Cancer Studies
Thyroid Cancer Diagnosis and Treatment
Oral Health Pathology and Treatment
[OBJECTIVE] While thyroid dysfunction during PD-L1 inhibitor therapy correlates with efficacy in recurrent/metastatic nasopharyngeal carcinoma, the prognostic value of basal thyroid function remains u
- 표본수 (n) 58
- p-value p = 0.011
- p-value p = 0.008
- 95% CI 0.36-0.88
APA
Keliang Chen, Haohan Fan, et al. (2026). Association of Basal Thyroid Function with Clinical Outcomes in Patients with Recurrent or Metastatic Nasopharyngeal Carcinoma Treated with PD-L1 Inhibitor KL-A167: A Multicenter Post-hoc Analysis.. Endocrine connections. https://doi.org/10.1530/EC-26-0083
MLA
Keliang Chen, et al.. "Association of Basal Thyroid Function with Clinical Outcomes in Patients with Recurrent or Metastatic Nasopharyngeal Carcinoma Treated with PD-L1 Inhibitor KL-A167: A Multicenter Post-hoc Analysis.." Endocrine connections, 2026.
PMID
41989879
Abstract
[OBJECTIVE] While thyroid dysfunction during PD-L1 inhibitor therapy correlates with efficacy in recurrent/metastatic nasopharyngeal carcinoma, the prognostic value of basal thyroid function remains unclear. This study investigated the relationship between baseline serum thyroid-stimulating hormone (TSH) and clinical outcomes.
[METHODS] We conducted a multicenter, retrospective analysis of 153 recurrent/metastatic nasopharyngeal carcinoma (R/M NPC) patients from a prospective phase 2 trial of the PD-L1 inhibitor KL-A167. Patients were stratified by baseline TSH levels. Multivariate Cox and logistic regression models were used to analyze Progression-Free Survival (PFS), Overall Survival (OS), and Objective Response Rate (ORR).
[RESULTS] High basal TSH (n = 58) was independently associated with significantly prolonged OS (HR 0.56, 95% CI: 0.36-0.88; p = 0.011) and PFS (HR 0.60, 95% CI: 0.41-0.87; p = 0.008) compared to the Low/Normal TSH group (n = 95). Although ORR was numerically higher in the High TSH group (27.6% vs. 17.9%), the difference was not statistically significant (p = 0.23). Subgroup analyses indicated consistent benefits across most clinical strata. Thyroid immune-related adverse events occurred in 32/153 (20.9%), similarly between groups (20.7% vs 21.1%, p = 0.957), and were not significantly associated with either OS (HR 0.65, 95% CI: 0.38-1.11, p = 0.117) or PFS (HR 0.88, 95% CI: 0.54-1.44, p = 0.613) by time-varying Cox regression.
[CONCLUSION] Elevated basal TSH levels are independently associated with improved survival in R/M NPC patients receiving KL-A167. Baseline TSH may serve as a simple, non-invasive biomarker for risk stratification and personalizing immunotherapy in this population.
[METHODS] We conducted a multicenter, retrospective analysis of 153 recurrent/metastatic nasopharyngeal carcinoma (R/M NPC) patients from a prospective phase 2 trial of the PD-L1 inhibitor KL-A167. Patients were stratified by baseline TSH levels. Multivariate Cox and logistic regression models were used to analyze Progression-Free Survival (PFS), Overall Survival (OS), and Objective Response Rate (ORR).
[RESULTS] High basal TSH (n = 58) was independently associated with significantly prolonged OS (HR 0.56, 95% CI: 0.36-0.88; p = 0.011) and PFS (HR 0.60, 95% CI: 0.41-0.87; p = 0.008) compared to the Low/Normal TSH group (n = 95). Although ORR was numerically higher in the High TSH group (27.6% vs. 17.9%), the difference was not statistically significant (p = 0.23). Subgroup analyses indicated consistent benefits across most clinical strata. Thyroid immune-related adverse events occurred in 32/153 (20.9%), similarly between groups (20.7% vs 21.1%, p = 0.957), and were not significantly associated with either OS (HR 0.65, 95% CI: 0.38-1.11, p = 0.117) or PFS (HR 0.88, 95% CI: 0.54-1.44, p = 0.613) by time-varying Cox regression.
[CONCLUSION] Elevated basal TSH levels are independently associated with improved survival in R/M NPC patients receiving KL-A167. Baseline TSH may serve as a simple, non-invasive biomarker for risk stratification and personalizing immunotherapy in this population.
같은 제1저자의 인용 많은 논문 (5)
- The Effect of Functional Rhinoplasty on Quality of Life: A Systematic Review and Meta-Analysis.
- Patient Management Strategies in Perioperative, Intraoperative, and Postoperative Period in Breast Reconstruction With DIEP-Flap: Clinical Recommendations.
- Optimizing the Use of Autografts, Allografts, and Alloplastic Materials in Rhinoplasty.
- Complement-secreting CAFs are associated with better prognosis in pancreatic cancer: single-cell multiomics.
- A Nanoimprinted Photothermal Chip for On-Demand Spatiotemporal Activation of CRISPR/Cas9 Gene Editing.