Hemophagocytic lymphohistiocytosis induced by radio-chemo-immunotherapy: a case report.
증례보고
3/5 보강
TL;DR
This case highlights the importance of early recognition and aggressive management of HLH secondary to immunotherapy, particularly in patients presenting with unexplained fever, G-CSF-refractory cytopenia, and hyperferritinemia.
연도별 인용 (2025–2026) · 합계 3
OpenAlex 토픽 ·
Autoimmune and Inflammatory Disorders Research
Immune Cell Function and Interaction
CNS Lymphoma Diagnosis and Treatment
This case highlights the importance of early recognition and aggressive management of HLH secondary to immunotherapy, particularly in patients presenting with unexplained fever, G-CSF-refractory cytop
APA
Bryan Salazar-Zuniga, Lorenz Thurner, et al. (2026). Hemophagocytic lymphohistiocytosis induced by radio-chemo-immunotherapy: a case report.. Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al], 202(5), 539-543. https://doi.org/10.1007/s00066-025-02478-w
MLA
Bryan Salazar-Zuniga, et al.. "Hemophagocytic lymphohistiocytosis induced by radio-chemo-immunotherapy: a case report.." Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al], vol. 202, no. 5, 2026, pp. 539-543.
PMID
41083745 ↗
Abstract 한글 요약
[BACKGROUND] Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening hyperinflammatory syndrome characterized by supramaximal immune activation. Although rare, HLH has been increasingly recognized as an immune-related adverse event in patients undergoing immune checkpoint inhibitor (ICI) therapy.
[CASE PRESENTATION] We report the case of a female patient treated with concomitant radio-chemo-immunotherapy for cervical cancer (according to the KEYNOTE-A18 trial). She developed HLH following a single dose of pembrolizumab, presenting initially with immune-mediated pneumonitis and subsequently with fever, prolonged pancytopenia, and elevated inflammatory markers. After intensive diagnostics, broad-spectrum anti-infective treatment and granulocyte colony-stimulating factor (G-CSF) stimulation was started, without improvement. The diagnosis was finally made by HLH-2004 criteria, strongly indicated by an H‑score of 251 (> 99% probability of HLH). The HLH was successfully treated with corticosteroids alone.
[CONCLUSION] This case highlights the importance of early recognition and aggressive management of HLH secondary to immunotherapy, particularly in patients presenting with unexplained fever, G‑CSF-refractory cytopenia, and hyperferritinemia.
[CASE PRESENTATION] We report the case of a female patient treated with concomitant radio-chemo-immunotherapy for cervical cancer (according to the KEYNOTE-A18 trial). She developed HLH following a single dose of pembrolizumab, presenting initially with immune-mediated pneumonitis and subsequently with fever, prolonged pancytopenia, and elevated inflammatory markers. After intensive diagnostics, broad-spectrum anti-infective treatment and granulocyte colony-stimulating factor (G-CSF) stimulation was started, without improvement. The diagnosis was finally made by HLH-2004 criteria, strongly indicated by an H‑score of 251 (> 99% probability of HLH). The HLH was successfully treated with corticosteroids alone.
[CONCLUSION] This case highlights the importance of early recognition and aggressive management of HLH secondary to immunotherapy, particularly in patients presenting with unexplained fever, G‑CSF-refractory cytopenia, and hyperferritinemia.
🏷️ 키워드 / MeSH 📖 같은 키워드 OA만
- Humans
- Lymphohistiocytosis
- Hemophagocytic
- Female
- Uterine Cervical Neoplasms
- Antibodies
- Monoclonal
- Humanized
- Chemoradiotherapy
- Granulocyte Colony-Stimulating Factor
- Middle Aged
- Immune Checkpoint Inhibitors
- Combined Modality Therapy
- Cytokine storm
- Hemophagocytic lymphohistiocytosis
- Immunotherapy adverse events
- Pembrolizumab
- Radio-chemo-immunotherapy
🏷️ 같은 키워드 · 무료전문 — 이 논문 MeSH/keyword 기반
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