Systematic Management of a Critical CYP3A4 Interaction Between Cabozantinib and Carbamazepine: A Case Report of a Clinically Relevant Pharmacokinetic Interaction.
증례보고
1/5 보강
This was the case of a 62-year-old patient treated with cabozantinib and nivolumab for metastatic clear cell renal cell carcinoma, in whom a clinically significant pharmacokinetic interaction with car
APA
Nizet P, Huon JF, et al. (2026). Systematic Management of a Critical CYP3A4 Interaction Between Cabozantinib and Carbamazepine: A Case Report of a Clinically Relevant Pharmacokinetic Interaction.. Clinical case reports, 14, e72563. https://doi.org/10.1002/ccr3.72563
MLA
Nizet P, et al.. "Systematic Management of a Critical CYP3A4 Interaction Between Cabozantinib and Carbamazepine: A Case Report of a Clinically Relevant Pharmacokinetic Interaction.." Clinical case reports, vol. 14, 2026, pp. e72563.
PMID
42040378 ↗
Abstract 한글 요약
This was the case of a 62-year-old patient treated with cabozantinib and nivolumab for metastatic clear cell renal cell carcinoma, in whom a clinically significant pharmacokinetic interaction with carbamazepine was observed. Carbamazepine, a potent inducer of CYP3A4, caused a major decrease in systemic exposure to cabozantinib, as confirmed by a residual plasma concentration well below the therapeutic target. An adaptation strategy based on identifying the interaction, gradually replacing carbamazepine with a noninducing anticonvulsant, temporarily adjusting the cabozantinib dosage, and close pharmacokinetic monitoring made it possible to restore effective concentrations without toxicity or neurological decompensation. This optimization was accompanied by a significant clinical improvement and radiological tumor control. This case has led to the ongoing need for a medication review before initiating this type of cancer treatment and the implementation of pharmacokinetic monitoring when an interaction was detected.
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