Per- and polyfluoroalkyl substance concentrations during pregnancy and at birth and risk of childhood acute lymphoblastic leukemia.
1/5 보강
[BACKGROUND] Per- and polyfluoroalkyl substances (PFAS) comprise a class of persistent environmental pollutants with potential carcinogenic effects, but their impact on childhood cancer remains undere
APA
Morimoto LM, Metayer C, et al. (2025). Per- and polyfluoroalkyl substance concentrations during pregnancy and at birth and risk of childhood acute lymphoblastic leukemia.. Environmental research, 285(Pt 3), 122436. https://doi.org/10.1016/j.envres.2025.122436
MLA
Morimoto LM, et al.. "Per- and polyfluoroalkyl substance concentrations during pregnancy and at birth and risk of childhood acute lymphoblastic leukemia.." Environmental research, vol. 285, no. Pt 3, 2025, pp. 122436.
PMID
40716601 ↗
Abstract 한글 요약
[BACKGROUND] Per- and polyfluoroalkyl substances (PFAS) comprise a class of persistent environmental pollutants with potential carcinogenic effects, but their impact on childhood cancer remains underexplored. A child's exposure to PFAS can occur through various pathways postnatally, including contaminated food, water, and consumer products; and in utero, as PFAS can cross the placenta.
[METHODS] To investigate the association between early-life PFAS exposure and the risk of childhood acute lymphoblastic leukemia (ALL), we analyzed archived blood samples from children diagnosed with ALL and matched cancer-free controls. Using novel untargeted liquid chromatography-high resolution mass spectrometry (LC-HRMS), we measured PFAS levels in paired maternal pregnancy and child newborn blood samples.
[RESULTS] Our study identified an independent association between MeFOSAA levels at birth and increased ALL risk, particularly among children diagnosed at 2 years of age or younger. MeFOSAA measured in maternal second-trimester blood showed a weak association with ALL, although it was not statistically significant.
[CONCLUSIONS] These results suggest that early-life exposure to MeFOSAA may play a critical role in the development of childhood ALL. Our findings corroborate previous reports linking MeFOSAA exposure during pregnancy to childhood ALL, highlighting its potential carcinogenicity during key developmental windows.
[METHODS] To investigate the association between early-life PFAS exposure and the risk of childhood acute lymphoblastic leukemia (ALL), we analyzed archived blood samples from children diagnosed with ALL and matched cancer-free controls. Using novel untargeted liquid chromatography-high resolution mass spectrometry (LC-HRMS), we measured PFAS levels in paired maternal pregnancy and child newborn blood samples.
[RESULTS] Our study identified an independent association between MeFOSAA levels at birth and increased ALL risk, particularly among children diagnosed at 2 years of age or younger. MeFOSAA measured in maternal second-trimester blood showed a weak association with ALL, although it was not statistically significant.
[CONCLUSIONS] These results suggest that early-life exposure to MeFOSAA may play a critical role in the development of childhood ALL. Our findings corroborate previous reports linking MeFOSAA exposure during pregnancy to childhood ALL, highlighting its potential carcinogenicity during key developmental windows.
🏷️ 키워드 / MeSH 📖 같은 키워드 OA만
- Humans
- Female
- Pregnancy
- Precursor Cell Lymphoblastic Leukemia-Lymphoma
- Infant
- Newborn
- Fluorocarbons
- Child
- Preschool
- Male
- Environmental Pollutants
- Prenatal Exposure Delayed Effects
- Maternal Exposure
- Adult
- Case-Control Studies
- Biomarkers
- Childhood leukemia
- Epidemiology
- Liquid chromatography-mass spectrometry
- PFAS
🏷️ 같은 키워드 · 무료전문 — 이 논문 MeSH/keyword 기반
- A Phase I Study of Hydroxychloroquine and Suba-Itraconazole in Men with Biochemical Relapse of Prostate Cancer (HITMAN-PC): Dose Escalation Results.
- Self-management of male urinary symptoms: qualitative findings from a primary care trial.
- Clinical and Liquid Biomarkers of 20-Year Prostate Cancer Risk in Men Aged 45 to 70 Years.
- Diagnostic accuracy of Ga-PSMA PET/CT versus multiparametric MRI for preoperative pelvic invasion in the patients with prostate cancer.
- Comprehensive analysis of androgen receptor splice variant target gene expression in prostate cancer.
- Clinical Presentation and Outcomes of Patients Undergoing Surgery for Thyroid Cancer.