Clinical and Biological Insights into Myelodysplastic Neoplasms Associated with Deletions of Chromosome 5q Region.
1/5 보강
The only cytogenetic alteration defining a subtype of a myelodysplastic syndrome is represented by the deletion of the long arm of chromosome 5 (del(5q)), now classified as MDS with isolated del(5q).
APA
Testa U, Castelli G, Pelosi E (2025). Clinical and Biological Insights into Myelodysplastic Neoplasms Associated with Deletions of Chromosome 5q Region.. Hematology reports, 17(6). https://doi.org/10.3390/hematolrep17060067
MLA
Testa U, et al.. "Clinical and Biological Insights into Myelodysplastic Neoplasms Associated with Deletions of Chromosome 5q Region.." Hematology reports, vol. 17, no. 6, 2025.
PMID
41440765 ↗
Abstract 한글 요약
The only cytogenetic alteration defining a subtype of a myelodysplastic syndrome is represented by the deletion of the long arm of chromosome 5 (del(5q)), now classified as MDS with isolated del(5q). This subtype is associated with a peculiar phenotype mainly dependent on the haploinsufficiency of several genes located on the deleted arm of chromosome 5. These patients show a good prognosis and respond to treatment with lenalidomide, but some cases progress to acute myeloid leukemia. Molecular studies have, in part, elucidated the heterogeneity of MDS with isolated del(5q), mainly related to the association with different co-mutations that may affect leukemic transformation and survival. In other MDS patients, del(5q) is combined with other chromosomal abnormalities, giving rise to a condition of complex karyotype, associated with frequent mutations and with a poor prognosis. Two different molecular pathways seem to be responsible for the generation of MDS with isolated del(5q) or of MDS with del(5q) associated with a complex karyotype.
🏷️ 키워드 / MeSH 📖 같은 키워드 OA만
🏷️ 같은 키워드 · 무료전문 — 이 논문 MeSH/keyword 기반
- Case Report: amplification in two adult patients with B-cell acute lymphoblastic leukemia.
- Rapid Transformation to Myeloid Blast Crisis in a Pediatric CML Patient Harboring a Complex t(7;9;22)(q11.23;q34;q11.2) Variant Translocation: A Case Report.
- Leveraging a spectrum of cytogenomics methods for profiling complex karyotypes in chronic lymphocytic leukemia.
- Acute promyelocytic leukemia with a unique genetic signature: a case report and management.
- A Rare Case of De Novo Acute Myeloid Leukemia, Featuring a () Amplification.
- Etiology of TP53 mutated complex karyotype acute myeloid leukemia.