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Different Survival Outcomes of Small Bowel Adenocarcinomas and T-Cell Lymphomas Associated With Celiac Disease.

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The American journal of gastroenterology 📖 저널 OA 20% 2021: 0/1 OA 2022: 0/1 OA 2023: 1/1 OA 2024: 3/8 OA 2025: 6/35 OA 2026: 8/41 OA 2021~2026 2025 Vol.120(12) p. 2949-2953
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Santacroce G, Vanoli A, Aronico N, Bianchi PI, Lenti MV, Ciacci C

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[INTRODUCTION] Small bowel adenocarcinoma (SBA) and T-cell lymphoma (TCL) are rare but aggressive malignancies associated with celiac disease (CD).

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  • p-value P < 0.01

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APA Santacroce G, Vanoli A, et al. (2025). Different Survival Outcomes of Small Bowel Adenocarcinomas and T-Cell Lymphomas Associated With Celiac Disease.. The American journal of gastroenterology, 120(12), 2949-2953. https://doi.org/10.14309/ajg.0000000000003574
MLA Santacroce G, et al.. "Different Survival Outcomes of Small Bowel Adenocarcinomas and T-Cell Lymphomas Associated With Celiac Disease.." The American journal of gastroenterology, vol. 120, no. 12, 2025, pp. 2949-2953.
PMID 40471829 ↗

Abstract

[INTRODUCTION] Small bowel adenocarcinoma (SBA) and T-cell lymphoma (TCL) are rare but aggressive malignancies associated with celiac disease (CD).

[METHODS] We retrospectively compared 43 CD-associated SBA and 43 CD-associated TCL across international referral centers.

[RESULTS] CD-associated SBA showed a significantly ( P < 0.01) better survival than CD-associated TCL. TCL more frequently presented with multifocal involvement and advanced stage, whereas SBA predominantly involved the jejunum. Refractoriness to a gluten-free diet was identified in 70% of TCL but only in one SBA.

[DISCUSSION] Our findings demonstrated a worse prognosis of CD-associated TCL in comparison with CD-associated SBA.

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