Analysis of risk factors for relapse after allogeneic hematopoietic stem cell transplantation in acute leukemia.
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[BACKGROUND] Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is an effective, and in many cases, the only treatment for curing malignant blood diseases.
- 95% CI 1.18-4.54
APA
Wang J, Zhu H, Miao K (2025). Analysis of risk factors for relapse after allogeneic hematopoietic stem cell transplantation in acute leukemia.. Hematology (Amsterdam, Netherlands), 30(1), 2532915. https://doi.org/10.1080/16078454.2025.2532915
MLA
Wang J, et al.. "Analysis of risk factors for relapse after allogeneic hematopoietic stem cell transplantation in acute leukemia.." Hematology (Amsterdam, Netherlands), vol. 30, no. 1, 2025, pp. 2532915.
PMID
40694687 ↗
Abstract 한글 요약
[BACKGROUND] Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is an effective, and in many cases, the only treatment for curing malignant blood diseases. However, post-transplant relapse is the primary factor affecting survival rates.
[METHODS] We conducted a retrospective analysis of 123 patients with acute leukemia undergoing allo-HSCT at Jiangsu Provincial People's Hospital from August 2017 to June 2023 to discuss the risk factors for relapse in acute leukemia (AL) patients after allo-HSCT.
[RESULTS] Among the 123 patients, 41experienced relapse, with 30 cases of relapse within one year. Multivariable analysis showed that pre-transplant MRD (+) and NR (HR 2.32, 95%CI 1.18-4.54, = 0.014), post-transplant MRD (+) (HR 2.13, 95%CI 1.04-4.36, = 0.016), cGVHD (-) (HR 0.48, 95%CI 0.23-0.97, = 0.041) and age < 40 (HR 0.44, 95%CI 0.23-0.83, = 0.011) were independent risk factors for relapse after allo-HSCT.
[CONCLUSIONS] Data from our center indicated that pre-transplant MRD (+) and NR, post-transplant MRD (+), cGVHD (-) and age < 40 are independent risk factors affecting relapse after allo-HSCT.
[METHODS] We conducted a retrospective analysis of 123 patients with acute leukemia undergoing allo-HSCT at Jiangsu Provincial People's Hospital from August 2017 to June 2023 to discuss the risk factors for relapse in acute leukemia (AL) patients after allo-HSCT.
[RESULTS] Among the 123 patients, 41experienced relapse, with 30 cases of relapse within one year. Multivariable analysis showed that pre-transplant MRD (+) and NR (HR 2.32, 95%CI 1.18-4.54, = 0.014), post-transplant MRD (+) (HR 2.13, 95%CI 1.04-4.36, = 0.016), cGVHD (-) (HR 0.48, 95%CI 0.23-0.97, = 0.041) and age < 40 (HR 0.44, 95%CI 0.23-0.83, = 0.011) were independent risk factors for relapse after allo-HSCT.
[CONCLUSIONS] Data from our center indicated that pre-transplant MRD (+) and NR, post-transplant MRD (+), cGVHD (-) and age < 40 are independent risk factors affecting relapse after allo-HSCT.
🏷️ 키워드 / MeSH 📖 같은 키워드 OA만
- Humans
- Hematopoietic Stem Cell Transplantation
- Risk Factors
- Male
- Female
- Adult
- Retrospective Studies
- Recurrence
- Middle Aged
- Adolescent
- Transplantation
- Homologous
- Young Adult
- Leukemia
- Myeloid
- Acute
- Precursor Cell Lymphoblastic Leukemia-Lymphoma
- Child
- Acute leukemia
- allogeneic hematopoietic stem cell transplantation
- relapse
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