Solitary Cutaneous Xanthogranuloma With DNMT3A Mutation Arising Postallogenic Transplant in a Patient With T-Cell Acute Lymphoblastic Leukemia.
1/5 보강
The development of a mature histiocytic neoplasm after an immature lymphoproliferative disorder is rare but well documented.
APA
Rinck JA, Boothby-Shoemaker W, Friedman BJ (2025). Solitary Cutaneous Xanthogranuloma With DNMT3A Mutation Arising Postallogenic Transplant in a Patient With T-Cell Acute Lymphoblastic Leukemia.. The American Journal of dermatopathology, 47(12), 954-956. https://doi.org/10.1097/DAD.0000000000003095
MLA
Rinck JA, et al.. "Solitary Cutaneous Xanthogranuloma With DNMT3A Mutation Arising Postallogenic Transplant in a Patient With T-Cell Acute Lymphoblastic Leukemia.." The American Journal of dermatopathology, vol. 47, no. 12, 2025, pp. 954-956.
PMID
40762954 ↗
Abstract 한글 요약
The development of a mature histiocytic neoplasm after an immature lymphoproliferative disorder is rare but well documented. Previous studies have demonstrated clonal relationships between these entities-often through T- and B-cell receptor clonality analyses-supporting the concept of transdifferentiation. We report a unique case of a solitary, subtle xanthogranuloma identified during routine comprehensive skin examination in a patient with a history of T-cell acute lymphoblastic lymphoma, postallogeneic stem cell transplant. Next-generation sequencing of the skin lesion revealed the presence of a DNMT3A mutation identical to that found in the patient's prior lymphoma, despite the patient being in both morphologic and molecular remission in the peripheral blood and bone marrow. This case underscores the importance of vigilant surveillance and highlights a potential mechanistic link through clonal evolution or transdifferentiation.
🏷️ 키워드 / MeSH 📖 같은 키워드 OA만
- Humans
- DNA (Cytosine-5-)-Methyltransferases
- DNA Methyltransferase 3A
- Mutation
- Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
- Skin Neoplasms
- Xanthomatosis
- clonal evolution
- hematopoietic stem cell transplantation
- high throughput nucleotide sequencing
- histiocytic neoplasm
- lymphoproliferative disorders
🏷️ 같은 키워드 · 무료전문 — 이 논문 MeSH/keyword 기반
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