Acute myeloid leukaemia cells express high levels of androgen receptor but do not depend on androgen signaling for survival.
1/5 보강
PICO 자동 추출 (휴리스틱, conf 2/4)
유사 논문P · Population 대상 환자/모집단
4281 patients treated with intensive chemotherapy in the AML17 and AML19 trials based on sex.
I · Intervention 중재 / 시술
추출되지 않음
C · Comparison 대조 / 비교
추출되지 않음
O · Outcome 결과 / 결론
We demonstrated high levels of androgen receptor (AR) expression in AML across cytogenetic risk groups.
Male sex is associated with worse outcome in acute myeloid leukemia (AML) in many studies.
APA
Miraki-Moud F, Ariza-McNaughton L, et al. (2025). Acute myeloid leukaemia cells express high levels of androgen receptor but do not depend on androgen signaling for survival.. Leukemia, 39(12), 2895-2906. https://doi.org/10.1038/s41375-025-02752-x
MLA
Miraki-Moud F, et al.. "Acute myeloid leukaemia cells express high levels of androgen receptor but do not depend on androgen signaling for survival.." Leukemia, vol. 39, no. 12, 2025, pp. 2895-2906.
PMID
40935826 ↗
Abstract 한글 요약
Male sex is associated with worse outcome in acute myeloid leukemia (AML) in many studies. We analyzed the survival of 4281 patients treated with intensive chemotherapy in the AML17 and AML19 trials based on sex. Men had a significantly lower remission rate than women. Men had a higher incidence of adverse cytogenetic features and a lower incidence of the relatively favorable NPM1 mutation. However, male sex was an independent risk factor for survival in multi-variate analysis. We hypothesized that androgen signaling in men could worsen outcomes by protecting AML cells from chemotherapy. We demonstrated high levels of androgen receptor (AR) expression in AML across cytogenetic risk groups. We showed the AR expression was induced by IL-6 signaling in vitro and correlates with poor overall survival. Androgens had no effect on survival of primary AML cells in vitro, nor did they impact gene expression. Androgens did not protect AML cells against chemotherapy either in vitro or in vivo. Similar results were observed with estrogen signaling through estrogen receptor in vitro in AML cells. In conclusion, targeting the androgen pathway may not be a promising clinical strategy and sex hormone signaling in AML cells does not explain the poorer outcomes of men.
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🏷️ 같은 키워드 · 무료전문 — 이 논문 MeSH/keyword 기반
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