EBV-Positive Diffuse Large B-Cell Lymphoma (DLBCL): An Assessment and a Roadmap.
1/5 보강
Diffuse large B-cell Lymphoma (DLBCL) is the most common lymphoma subtype worldwide.
APA
Porcu P, Masel R, et al. (2025). EBV-Positive Diffuse Large B-Cell Lymphoma (DLBCL): An Assessment and a Roadmap.. Journal of medical virology, 97(12), e70722. https://doi.org/10.1002/jmv.70722
MLA
Porcu P, et al.. "EBV-Positive Diffuse Large B-Cell Lymphoma (DLBCL): An Assessment and a Roadmap.." Journal of medical virology, vol. 97, no. 12, 2025, pp. e70722.
PMID
41307390 ↗
Abstract 한글 요약
Diffuse large B-cell Lymphoma (DLBCL) is the most common lymphoma subtype worldwide. The Epstein Barr Virus (EBV) is a human DNA virus associated with a spectrum of human malignancies. EBV is detected in 5% to 15% of DLBCL tumors with no history of immunosuppression. Early reports of EBV-positive DLBCL suggested distinct clinical presentation, unique tumor microenvironment (TME), and inferior survival compared to EBV-negative DLBCL. A better definition of EBV-positive cases treated with modern chemo-immunotherapy has recently improved our understanding of this entity. Recent studies have provided initial insights into the distinct mutational landscape and immune microenvironment of EBV-positive DLBCL and identified EBV as an independent prognostic biomarker in DLBCL. Despite these advances, fundamental questions remain. We provide an overview of emerging clinical and molecular aspects of EBV-positive DLBCL and discuss recent efforts to develop EBV-targeting therapies. We also discuss key research questions in EBV-positive DLBCL.
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