Transcatheter Aortic Valve Replacement Associated With Fibrin-Associated Large B-Cell Lymphoma.
[BACKGROUND] Fibrin-associated large B-cell lymphoma (FA-LBCL) is a rare disorder, but its role in transcatheter valve failure is unknown.
APA
Tharakan AK, Hoffhines A, et al. (2025). Transcatheter Aortic Valve Replacement Associated With Fibrin-Associated Large B-Cell Lymphoma.. JACC. Case reports, 30(40), 105841. https://doi.org/10.1016/j.jaccas.2025.105841
MLA
Tharakan AK, et al.. "Transcatheter Aortic Valve Replacement Associated With Fibrin-Associated Large B-Cell Lymphoma.." JACC. Case reports, vol. 30, no. 40, 2025, pp. 105841.
PMID
41386955
Abstract
[BACKGROUND] Fibrin-associated large B-cell lymphoma (FA-LBCL) is a rare disorder, but its role in transcatheter valve failure is unknown. This report describes the first documented case of FA-LBCL in a transcatheter aortic valve.
[FIRST-IN-HUMAN/EARLY REPORTS SUMMARY] A 62-year-old man with a prior transcatheter aortic valve replacement presented with symptomatic severe aortic stenosis. Histopathologic analysis of the explanted valve revealed FA-LBCL as the primary cause of valve failure.
[DISCUSSION] This case established a neoplastic process as a cause of structural valve degeneration (SVD) in transcatheter valves. It highlights that FA-LBCL should be included in the differential diagnosis of transcatheter aortic valve replacement failure, for which surgical explantation can be both diagnostic and curative.
[NOVELTY] This is the first report that documents FA-LBCL causing SVD of a transcatheter bioprosthetic valve.
[TAKE-HOME MESSAGES] FA-LBCL represents a cause of SVD in transcatheter bioprosthetic valves. This diagnosis should be considered in cases of premature valve failure.
[FIRST-IN-HUMAN/EARLY REPORTS SUMMARY] A 62-year-old man with a prior transcatheter aortic valve replacement presented with symptomatic severe aortic stenosis. Histopathologic analysis of the explanted valve revealed FA-LBCL as the primary cause of valve failure.
[DISCUSSION] This case established a neoplastic process as a cause of structural valve degeneration (SVD) in transcatheter valves. It highlights that FA-LBCL should be included in the differential diagnosis of transcatheter aortic valve replacement failure, for which surgical explantation can be both diagnostic and curative.
[NOVELTY] This is the first report that documents FA-LBCL causing SVD of a transcatheter bioprosthetic valve.
[TAKE-HOME MESSAGES] FA-LBCL represents a cause of SVD in transcatheter bioprosthetic valves. This diagnosis should be considered in cases of premature valve failure.