Undetectable IgE association with noninfectious complications of common variable immune deficiency.
1/5 보강
PICO 자동 추출 (휴리스틱, conf 2/4)
유사 논문P · Population 대상 환자/모집단
60 patients with CVID with detectable IgE and 89 patients with CVID with undetectable IgE.
I · Intervention 중재 / 시술
추출되지 않음
C · Comparison 대조 / 비교
추출되지 않음
O · Outcome 결과 / 결론
Undetectable IgE was associated with a significantly higher frequency of autoimmune cytopenias and lymphoma and trends toward higher relative frequencies of serious bacterial infections and granulomatous disease. [CONCLUSION] Undetectable IgE is a readily available biomarker that in a patient with CVID may direct clinicians to be particularly vigilant for noninfectious complications of CVID.
[BACKGROUND] Undetectable IgE levels are a frequent feature of common variable immunodeficiency (CVID).
APA
D'Silva SJ, Patrie J, et al. (2025). Undetectable IgE association with noninfectious complications of common variable immune deficiency.. Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology. https://doi.org/10.1016/j.anai.2025.12.003
MLA
D'Silva SJ, et al.. "Undetectable IgE association with noninfectious complications of common variable immune deficiency.." Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 2025.
PMID
41390140
Abstract
[BACKGROUND] Undetectable IgE levels are a frequent feature of common variable immunodeficiency (CVID). However, not much is known regarding the role of IgE levels as a prognostic factor in patients with CVID.
[OBJECTIVE] To evaluate whether undetectable IgE levels would be associated with higher risk of noninfectious complications of CVID.
[METHODS] We compared clinical and laboratory outcomes in 60 patients with CVID with detectable IgE and 89 patients with CVID with undetectable IgE.
[RESULTS] Undetectable IgE was associated with significantly lower IgG, IgM, and IgA concentrations. In addition, these patients had significantly lower numbers of CD4+ T cells, total B cells, plasmablasts, and reduced memory and especially switch memory B cells, but no difference in CD21low B cells. Undetectable IgE was associated with a significantly higher frequency of autoimmune cytopenias and lymphoma and trends toward higher relative frequencies of serious bacterial infections and granulomatous disease.
[CONCLUSION] Undetectable IgE is a readily available biomarker that in a patient with CVID may direct clinicians to be particularly vigilant for noninfectious complications of CVID.
[OBJECTIVE] To evaluate whether undetectable IgE levels would be associated with higher risk of noninfectious complications of CVID.
[METHODS] We compared clinical and laboratory outcomes in 60 patients with CVID with detectable IgE and 89 patients with CVID with undetectable IgE.
[RESULTS] Undetectable IgE was associated with significantly lower IgG, IgM, and IgA concentrations. In addition, these patients had significantly lower numbers of CD4+ T cells, total B cells, plasmablasts, and reduced memory and especially switch memory B cells, but no difference in CD21low B cells. Undetectable IgE was associated with a significantly higher frequency of autoimmune cytopenias and lymphoma and trends toward higher relative frequencies of serious bacterial infections and granulomatous disease.
[CONCLUSION] Undetectable IgE is a readily available biomarker that in a patient with CVID may direct clinicians to be particularly vigilant for noninfectious complications of CVID.