Histological subtypes of rheumatoid arthritis-associated lymphoproliferative disorders: Serological and Epstein-Barr virus findings.
[OBJECTIVES] Lymphoproliferative disorders (LPD) in patients with rheumatoid arthritis (RA) are thought to develop through two major mechanisms: chronic inflammation and immunosuppression.
- p-value p = 0.024
- p-value p < 0.001
APA
Kinoshita K, Miyake H, et al. (2025). Histological subtypes of rheumatoid arthritis-associated lymphoproliferative disorders: Serological and Epstein-Barr virus findings.. Modern rheumatology. https://doi.org/10.1093/mr/roaf125
MLA
Kinoshita K, et al.. "Histological subtypes of rheumatoid arthritis-associated lymphoproliferative disorders: Serological and Epstein-Barr virus findings.." Modern rheumatology, 2025.
PMID
41384754
Abstract
[OBJECTIVES] Lymphoproliferative disorders (LPD) in patients with rheumatoid arthritis (RA) are thought to develop through two major mechanisms: chronic inflammation and immunosuppression. This study aimed to investigate the relationship between histological subtypes and two representative biomarkers, rheumatoid factor (RF) and Epstein-Barr virus-encoded RNA in situ hybridisation (EBER-ISH), in RA-associated LPD (RA-LPD).
[METHODS] We retrospectively analysed patients with clinically diagnosed RA-LPD who underwent tissue biopsy at a single institution. Histological subtypes were classified as classic Hodgkin lymphoma (CHL), monomorphic LPD (Mono-LPD), polymorphic LPD (Poly-LPD), or reactive lymphoid hyperplasia/normal variant (RLH/NV). RF levels and EBER-ISH results were compared across groups.
[RESULTS] A total of 69 RA-LPD patients were included in the analysis. RF levels differed significantly across the four histological subtypes (p = 0.024), with the highest median level observed in the Mono-LPD group. EBER-ISH positivity differed significantly among the subtypes (p < 0.001), with a significantly higher rate in Poly-LPD compared to Mono-LPD and RLH/NV. Mono-LPD tended to show high RF titres and EBER-ISH negativity, whereas Poly-LPD and CHL were characterised by low RF titres and high EBER-ISH positivity.
[CONCLUSIONS] RF and EBER-ISH status differed among histological subtypes of RA-LPD, and their combined assessment may help explain its histological diversity.
[METHODS] We retrospectively analysed patients with clinically diagnosed RA-LPD who underwent tissue biopsy at a single institution. Histological subtypes were classified as classic Hodgkin lymphoma (CHL), monomorphic LPD (Mono-LPD), polymorphic LPD (Poly-LPD), or reactive lymphoid hyperplasia/normal variant (RLH/NV). RF levels and EBER-ISH results were compared across groups.
[RESULTS] A total of 69 RA-LPD patients were included in the analysis. RF levels differed significantly across the four histological subtypes (p = 0.024), with the highest median level observed in the Mono-LPD group. EBER-ISH positivity differed significantly among the subtypes (p < 0.001), with a significantly higher rate in Poly-LPD compared to Mono-LPD and RLH/NV. Mono-LPD tended to show high RF titres and EBER-ISH negativity, whereas Poly-LPD and CHL were characterised by low RF titres and high EBER-ISH positivity.
[CONCLUSIONS] RF and EBER-ISH status differed among histological subtypes of RA-LPD, and their combined assessment may help explain its histological diversity.