Influenza-Specific T-Cell Responses to Vaccination Are Independent of Underlying Hematological Malignancy: Analysis of a Randomized Influenza Vaccination Trial.
[BACKGROUND] There are few in-depth immunogenicity analyses of novel influenza vaccination strategies in high-risk patients with hematological malignancy (HM).
- p-value P < .001
- p-value P < .05
- 연구 설계 randomized controlled trial
APA
Hall VG, Nguyen THO, et al. (2025). Influenza-Specific T-Cell Responses to Vaccination Are Independent of Underlying Hematological Malignancy: Analysis of a Randomized Influenza Vaccination Trial.. The Journal of infectious diseases, 232(6), 1319-1329. https://doi.org/10.1093/infdis/jiaf297
MLA
Hall VG, et al.. "Influenza-Specific T-Cell Responses to Vaccination Are Independent of Underlying Hematological Malignancy: Analysis of a Randomized Influenza Vaccination Trial.." The Journal of infectious diseases, vol. 232, no. 6, 2025, pp. 1319-1329.
PMID
40600710
Abstract
[BACKGROUND] There are few in-depth immunogenicity analyses of novel influenza vaccination strategies in high-risk patients with hematological malignancy (HM).
[METHODS] Participants receiving treatment for active HM (multiple myeloma [MM], chronic lymphocytic leukemia [CLL], or non-Hodgkin lymphoma [NHL]) in a randomized controlled trial of 2 doses of adjuvanted quadrivalent inactivated influenza vaccine (QIV) versus 2 doses of standard-dose QIV during 2022 were included. Hemagglutination (HA) inhibition assay and HA probe-specific B-cells were compared at baseline and 1, 2, and 6 months after the first vaccine dose (visits 1-4). A subset underwent ex vivo live virus infection of peripheral blood mononuclear cells at visits 1 and 3 with A/H1N1 and A/H3N2 to assess interferon (IFN) γ-producing CD4+ T cells, CD8+ T cells, natural killer cells, CD161+TRAV1-2+ mucosal-associated invariant T (MAIT)-like T cells and γδ T cells.
[RESULTS] In total, 62 patients with HM were analyzed (32 in the adjuvanted-dose and 30 in the standard-dose group), 13 (21.0%) with CLL, 24 (38.7%) MM, and 25 (40.3%) with NHL. Participants with MM had higher geometric mean antibody titers (P < .001) and influenza-specific B-cell responses for H1, H3, and B/Victoria at visits 2 and 3 than those with CLL or NHL (P < .05). The total CD19+ B-cell and HA probe-specific B-cell counts were found to significantly predict seroconversion at visits 2 and 3. Overall, with vaccination, there was an increase in the percentage frequency of B/Victoria influenza-specific B-cells (P = .01), IFN-γ-producing CD4+ T cells (P = .01) for A/H1N1 and IFN-γ-producing MAIT-like cells (P = .003) for A/H3N2.
[CONCLUSIONS] Influenza strain-specific cellular responses were detectable following vaccination despite expected B-cell depletion in patients receiving active treatment for HM.
[CLINICAL TRIALS REGISTRATION] Australian New Zealand Clinical Trials Registry ACTRN12622000454774.
[METHODS] Participants receiving treatment for active HM (multiple myeloma [MM], chronic lymphocytic leukemia [CLL], or non-Hodgkin lymphoma [NHL]) in a randomized controlled trial of 2 doses of adjuvanted quadrivalent inactivated influenza vaccine (QIV) versus 2 doses of standard-dose QIV during 2022 were included. Hemagglutination (HA) inhibition assay and HA probe-specific B-cells were compared at baseline and 1, 2, and 6 months after the first vaccine dose (visits 1-4). A subset underwent ex vivo live virus infection of peripheral blood mononuclear cells at visits 1 and 3 with A/H1N1 and A/H3N2 to assess interferon (IFN) γ-producing CD4+ T cells, CD8+ T cells, natural killer cells, CD161+TRAV1-2+ mucosal-associated invariant T (MAIT)-like T cells and γδ T cells.
[RESULTS] In total, 62 patients with HM were analyzed (32 in the adjuvanted-dose and 30 in the standard-dose group), 13 (21.0%) with CLL, 24 (38.7%) MM, and 25 (40.3%) with NHL. Participants with MM had higher geometric mean antibody titers (P < .001) and influenza-specific B-cell responses for H1, H3, and B/Victoria at visits 2 and 3 than those with CLL or NHL (P < .05). The total CD19+ B-cell and HA probe-specific B-cell counts were found to significantly predict seroconversion at visits 2 and 3. Overall, with vaccination, there was an increase in the percentage frequency of B/Victoria influenza-specific B-cells (P = .01), IFN-γ-producing CD4+ T cells (P = .01) for A/H1N1 and IFN-γ-producing MAIT-like cells (P = .003) for A/H3N2.
[CONCLUSIONS] Influenza strain-specific cellular responses were detectable following vaccination despite expected B-cell depletion in patients receiving active treatment for HM.
[CLINICAL TRIALS REGISTRATION] Australian New Zealand Clinical Trials Registry ACTRN12622000454774.
MeSH Terms
Humans; Influenza Vaccines; Male; Female; Influenza, Human; Middle Aged; Hematologic Neoplasms; Aged; Influenza A Virus, H1N1 Subtype; Influenza A Virus, H3N2 Subtype; Vaccination; T-Lymphocytes; Adult; Hemagglutination Inhibition Tests; B-Lymphocytes; Antibodies, Viral; Vaccines, Inactivated