AN INFILTRATIVE CHOROIDAL LESION.
1/5 보강
[PURPOSE] To present a distinctive case of primary choroidal lymphoma diagnosed by choroidal biopsy with myeloid differentiation primary response 88 testing.
APA
Li Y, Gabr H, Mieler WF (2026). AN INFILTRATIVE CHOROIDAL LESION.. Retinal cases & brief reports, 20(1), 168-171. https://doi.org/10.1097/ICB.0000000000001702
MLA
Li Y, et al.. "AN INFILTRATIVE CHOROIDAL LESION.." Retinal cases & brief reports, vol. 20, no. 1, 2026, pp. 168-171.
PMID
39666859
Abstract
[PURPOSE] To present a distinctive case of primary choroidal lymphoma diagnosed by choroidal biopsy with myeloid differentiation primary response 88 testing.
[METHODS] We describe the case of a 55-year-old man with unilateral progressive blurry vision. Fundus examination found a whitish/yellowish infiltrative lesion in the posterior pole with macular edema, which had interval improvement with oral prednisone, followed by worsening on optical coherence tomography with persistent subretinal hyper-reflective materials.
[RESULTS] Because the initial pars plana vitrectomy/vitreous biopsy and choroidal fine needle aspiration biopsy were inconclusive, the second fine needle aspiration biopsy was performed with an additional myeloid differentiation primary response 88 genetic test that revealed a rare in-frame deletion of myeloid differentiation primary response 88 (p.D288_T294del) in the choroidal sample.
[CONCLUSION] The diagnosis of primary choroidal lymphoma was eventually established. After treatment with methotrexate, followed by external beam radiotherapy, the choroidal infiltrate was normalized on B scan.
[METHODS] We describe the case of a 55-year-old man with unilateral progressive blurry vision. Fundus examination found a whitish/yellowish infiltrative lesion in the posterior pole with macular edema, which had interval improvement with oral prednisone, followed by worsening on optical coherence tomography with persistent subretinal hyper-reflective materials.
[RESULTS] Because the initial pars plana vitrectomy/vitreous biopsy and choroidal fine needle aspiration biopsy were inconclusive, the second fine needle aspiration biopsy was performed with an additional myeloid differentiation primary response 88 genetic test that revealed a rare in-frame deletion of myeloid differentiation primary response 88 (p.D288_T294del) in the choroidal sample.
[CONCLUSION] The diagnosis of primary choroidal lymphoma was eventually established. After treatment with methotrexate, followed by external beam radiotherapy, the choroidal infiltrate was normalized on B scan.
MeSH Terms
Humans; Male; Middle Aged; Choroid Neoplasms; Tomography, Optical Coherence; Choroid
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