Occurrence and predictors of patient reported fertility discussions in non-Hodgkin lymphoma patients: utilizing the lymphoma epidemiology of outcomes (LEO) cohort study.

Patients with non-Hodgkin lymphoma (NHL), especially younger individuals, can face fertility risks from treatment. We assessed rates and predictors of fertility counseling and preservation in this population. The LEO cohort prospectively enrolled newly diagnosed NHL patients (2015-2020) at eight U.S. academic centers. We assessed responses to a 3-year survivorship questionnaire in those aged 18-50 at diagnosis; logistic regression evaluated predictors of fertility counseling. Of 77 respondents included (46% female, median age 40), 72.2% of females and 58.5% of males recalled having a fertility discussion at diagnosis. Fertility counseling was more likely to occur in those aged 18-39 versus 40-50 (OR 10.2, 95% CI 3.3-39.2) and in those receiving alkylating therapy (OR 9.0, 95% CI 2.3-45.5). Interventions are still needed to ensure adequate survivorship care.