Homocysteine-driven oxidative stress in pediatric lymphoma: a cross-sectional study of metabolic and genetic modulators.
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Hyperhomocysteinemia and oxidative stress are increasingly recognized in pediatric malignancies, but their interplay remains unclear.
APA
Dadashova A, Aliyeva G, et al. (2026). Homocysteine-driven oxidative stress in pediatric lymphoma: a cross-sectional study of metabolic and genetic modulators.. Leukemia & lymphoma, 67(2), 332-341. https://doi.org/10.1080/10428194.2025.2586081
MLA
Dadashova A, et al.. "Homocysteine-driven oxidative stress in pediatric lymphoma: a cross-sectional study of metabolic and genetic modulators.." Leukemia & lymphoma, vol. 67, no. 2, 2026, pp. 332-341.
PMID
41217064 ↗
Abstract 한글 요약
Hyperhomocysteinemia and oxidative stress are increasingly recognized in pediatric malignancies, but their interplay remains unclear. We evaluated homocysteine metabolism, vitamin cofactor status, and oxidative stress in 90 children with newly diagnosed lymphoma before chemotherapy. Plasma homocysteine, folate, vitamins B and B, and oxidative stress markers (8-OHdG, nitrotyrosine, protein carbonyls, NO, iNOS) were measured, alongside C677T genotyping. Hyperhomocysteinemia (>15 μmol/L) was present in 96% ( = 87), with low folate (median 2.6 ng/mL) and B deficiency (B<200 pg/mL in 84%, = 76). Homocysteine correlated inversely with folate and B, and positively with 8-OHdG ( < 0.05). 677CT carriers had markedly elevated nitrotyrosine and higher 8-OHdG ( < 0.05), independent of homocysteine levels. In multivariate analysis, the T-allele predicted nitrotyrosine ( < 0.05), while homocysteine did not. These findings demonstrate profound disruption of one-carbon metabolism and oxidative stress in pediatric lymphoma at diagnosis, with genetic and micronutrient factors modulating the oxidative burden, emphasizing the value of early metabolic assessment.
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