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Effect of colostrum replacer containing bovine leukemia virus antibodies on infection and antibody level in young calves.

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Journal of dairy science 2026 Vol.109(1) p. 584-591 OA
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Matsuda KI, Arai T, Shiobara M, Kimura A, Ichijho T, Murakami K

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In this study, we aimed to investigate whether a commercially available spray-dried colostrum replacer containing bovine leukemia virus (BLV) antibodies could increase serum antibody levels and preven

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APA Matsuda KI, Arai T, et al. (2026). Effect of colostrum replacer containing bovine leukemia virus antibodies on infection and antibody level in young calves.. Journal of dairy science, 109(1), 584-591. https://doi.org/10.3168/jds.2025-27090
MLA Matsuda KI, et al.. "Effect of colostrum replacer containing bovine leukemia virus antibodies on infection and antibody level in young calves.." Journal of dairy science, vol. 109, no. 1, 2026, pp. 584-591.
PMID 41342701 ↗

Abstract

In this study, we aimed to investigate whether a commercially available spray-dried colostrum replacer containing bovine leukemia virus (BLV) antibodies could increase serum antibody levels and prevent early BLV infection in newborn calves. The sample-to-positive ratio (S/P value) of anti-BLV antibodies in 10 batches of the colostrum replacer was 2.48 ± 0.33 (positive value ≥0.3), as determined by ELISA. Fourteen calves born to BLV-negative mothers and fed maternal colostrum were assigned to the control group. Another 14 calves, separated from their dams immediately after birth and fed 450 g of colostrum replacer within 6 h, formed the test group. Calves were allocated into groups alternately by birth order. Serum S/P ratio of BLV antibodies was monitored d 1 to 84. The control group maintained near-zero antibody levels throughout the study period. Conversely, the test group had an antibody value of 2.36 ± 0.54 on d 1, which declined over time but remained positive in all calves until d 56. These results suggest that colostrum replacers containing BLV antibodies can confer passive immunity and reduce early-life BLV infection risk.

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