High-grade/large B-cell lymphoma-11q has a very good prognosis in children and young people without a predisposition.

Ronceray L; Huibers MHW; Reutter K; Abla O; Andrés M; Balagué O; Csóka M; Gilad G; Hagleitner MM; Hori D; Hjalgrim LL; Jazbec J; Klapper W; Nakazawa A; Verdú-Amorós J; von Mersi H; Wössmann W; Xavier AC; Burkhardt B; Salaverria I; Attarbaschi A

doi:10.1182/blood.2025031086

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High-grade/large B-cell lymphoma-11q has a very good prognosis in children and young people without a predisposition.

Blood 2026 Vol.147(2) p. 209-214

Ronceray L, Huibers MHW, Reutter K, Abla O, Andrés M, Balagué O, Csóka M, Gilad G, Hagleitner MM, Hori D, Hjalgrim LL, Jazbec J, Klapper W, Nakazawa A, Verdú-Amorós J, von Mersi H, Wössmann W, Xavier AC, Burkhardt B, Salaverria I, Attarbaschi A

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High-grade B-cell lymphoma with 11q aberration (HGBCL-11q) is a rare pediatric non-Hodgkin lymphoma.

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APA Ronceray L, Huibers MHW, et al. (2026). High-grade/large B-cell lymphoma-11q has a very good prognosis in children and young people without a predisposition.. Blood, 147(2), 209-214. https://doi.org/10.1182/blood.2025031086

MLA Ronceray L, et al.. "High-grade/large B-cell lymphoma-11q has a very good prognosis in children and young people without a predisposition.." Blood, vol. 147, no. 2, 2026, pp. 209-214.

PMID 41160801

DOI 10.1182/blood.2025031086

Abstract

High-grade B-cell lymphoma with 11q aberration (HGBCL-11q) is a rare pediatric non-Hodgkin lymphoma. This study assessed outcome in 90 children with HGBCL-11q. With survival rates ≥95%, patients with HGBCL-11q and no predisposition are candidates for deescalated therapy in future prospective trials.

MeSH Terms

Humans; Child; Adolescent; Prognosis; Female; Male; Child, Preschool; Lymphoma, Large B-Cell, Diffuse; Chromosomes, Human, Pair 11; Infant; Genetic Predisposition to Disease; Neoplasm Grading