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CPX-351 in Down syndrome-associated myeloid leukemia: results and prognostic factors from the phase 3 ML-DS 2018 trial.

1/5 보강

Blood 📖 저널 OA 52.5% 2025~2026 2026 Vol.147(3) p. 229-240 OA

PICO 자동 추출 (휴리스틱, conf 3/4)

P · Population 대상 환자/모집단

35 patients were enrolled until the trial was halted because of an unexpectedly high relapse rate.

I · Intervention 중재 / 시술

high-dose cytarabine (3 g/m2 per 12 hour) in consolidation; standard-risk patients received cytarabine at a dose of 1 g/m2 per 12 hour

C · Comparison 대조 / 비교

추출되지 않음

O · Outcome 결과 / 결론

In conclusion, replacing intensity-reduced induction therapy with CPX-351 in ML-DS led to a significantly lower EFS, highlighting the need for dose optimization to balance the efficacy and toxicity in this sensitive patient population.

Laszig S, Diederichs A, Salzmann-Manrique E, Schuschel K, Gonçalves-Dias J, Issa H

📖 무료 전문 🟢 PMC 전문 PMC12824674 🔓 OA PDF unpaywall · cc-by-nc-nd

PubMed ↗ DOI ↗ BibTeX ↓ RIS ↓

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