Cutting without cleaving: How caspase-1 shapes leukemia beyond enzymatic activity.
In this issue of Cell Chemical Biology, Uible et al.
APA
Braun LM, Zeiser R (2026). Cutting without cleaving: How caspase-1 shapes leukemia beyond enzymatic activity.. Cell chemical biology, 33(1), 1-3. https://doi.org/10.1016/j.chembiol.2025.12.011
MLA
Braun LM, et al.. "Cutting without cleaving: How caspase-1 shapes leukemia beyond enzymatic activity.." Cell chemical biology, vol. 33, no. 1, 2026, pp. 1-3.
PMID
41544612
Abstract
In this issue of Cell Chemical Biology, Uible et al. uncover a previously unknown non-proteolytic role for caspase-1 (CASP1) in leukemia. CASP1 sustains leukemic growth by coordinating mTORC1-NF-κB signaling as scaffold for RPTOR, rather than regulating IL-1β and pyroptosis. CASP1's scaffolding function was found as a therapeutic vulnerability in leukemia.
MeSH Terms
Caspase 1; Humans; Leukemia; NF-kappa B; Signal Transduction; Mechanistic Target of Rapamycin Complex 1