[Efficacy of axi-cel in a patient with high-grade large B-cell lymphoma refractory to first-line therapy: importance of early identification and referral of the patient potentially eligible for CAR-T in defining the patient's outcome].
1/5 보강
CAR-T cell therapy has revolutionized second-line treatment for patients with refractory/relapsed large B-cell lymphoma within 12 months, demonstrating clear superiority in terms of both response rate
APA
Casadei B, Zinzani PL (2026). [Efficacy of axi-cel in a patient with high-grade large B-cell lymphoma refractory to first-line therapy: importance of early identification and referral of the patient potentially eligible for CAR-T in defining the patient's outcome].. Recenti progressi in medicina, 117(2), e29-e32. https://doi.org/10.1701/4649.46632
MLA
Casadei B, et al.. "[Efficacy of axi-cel in a patient with high-grade large B-cell lymphoma refractory to first-line therapy: importance of early identification and referral of the patient potentially eligible for CAR-T in defining the patient's outcome].." Recenti progressi in medicina, vol. 117, no. 2, 2026, pp. e29-e32.
PMID
41716106 ↗
Abstract 한글 요약
CAR-T cell therapy has revolutionized second-line treatment for patients with refractory/relapsed large B-cell lymphoma within 12 months, demonstrating clear superiority in terms of both response rate and survival compared to salvage chemotherapy followed by autologous stem cell transplantation (auto-SCT). In this setting, CAR-T therapy also appears to overcome the poor prognosis associated with a diagnosis of high-grade B-cell lymphoma (HGBCL), as demonstrated by both clinical studies and real-world data, changing the outcome for a population of patients who would otherwise have no valid therapeutic alternatives. The diagnosis of HGBCL and a lack of complete response to interim re-evaluation during first-line therapy should lead to a CAR-T program, allowing for early referral and therefore rapid access to this cell therapy, impacting the outcome of the therapy itself.
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