[Research Progress of Megakaryocyte Morphology in the Prognosis of Primary Myelofibrosis--Review].
1/5 보강
Primary myelofibrosis (PMF) is a myeloproliferative neoplasm (MPN) characterized by malignancy derived from hematopoietic stem cells.
APA
Zheng ZK, Huang J (2026). [Research Progress of Megakaryocyte Morphology in the Prognosis of Primary Myelofibrosis--Review].. Zhongguo shi yan xue ye xue za zhi, 34(1), 293-297. https://doi.org/10.19746/j.cnki.issn.1009-2137.2026.01.043
MLA
Zheng ZK, et al.. "[Research Progress of Megakaryocyte Morphology in the Prognosis of Primary Myelofibrosis--Review].." Zhongguo shi yan xue ye xue za zhi, vol. 34, no. 1, 2026, pp. 293-297.
PMID
41846372 ↗
Abstract 한글 요약
Primary myelofibrosis (PMF) is a myeloproliferative neoplasm (MPN) characterized by malignancy derived from hematopoietic stem cells. Compared with polycythemia vera (PV) and essential thrombocythemia (ET), PMF shows a worse clinical prognosis. Therefore, it is essential to explore biological markers for early identification and intervention to delay the process of the disease. Megakaryocytes (MK) play a central role in the pathogenesis and disease progression of PMF. The thrombophilia, the aggravation of myelofibrosis and the transformation to acute myeloid leukemia (AML) in patients with PMF are closely related to the morphological characteristics of MK.Changes in MK morphology are not only regulated by inflammatory mediators, but also influenced by specific genetic factors. This article will review the mechanism of MK morphological changes in PMF and the latest research progress on the prognosis of PMF with MK morphology, so as to provide reference for early clinical diagnosis and treatment.
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🏷️ 같은 키워드 · 무료전문 — 이 논문 MeSH/keyword 기반
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