[Analysis of factors influencing the prognosis of pediatric acute myeloid leukemia based on minimal residual disease with different detection methods].

A retrospective analysis was conducted on the clinical data of newly diagnosed pediatric acute myeloid leukemia (AML) children [excluding acute promyelocytic leukemia (APL)] in Shanghai Children's Hospital between January 2019 and April 2024. The patients were followed up until April 30, 2025. Minimal residual disease (MRD) was detected to analyze the prognostic impact of MRD assessed by different methods on pediatric AML patients. Among the 52 enrolled patients, 35 were male and 17 were female. The median age at initial diagnosis was 99 months (range: 9-188 months), with a median follow-up [ (, )] of 3.2 (1.2, 4.7) years. The 3-year overall survival rates and event-free survival (EFS) rates were 80.7% and 69.4%, respectively. Multivariate Cox regression analysis revealed that gene MLL rearrangement (excluding MLL-AF9) (=3.071, 95%: 1.024-9.205) and positive molecular MRD after Induction Course Ⅱ therapy (=5.571, 95%: 1.244-24.957) were risk factors for EFS in pediatric AML patients.