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Laugier-Hunziker Syndrome Diagnosed by a Medical Student After Multiple Failed Specialist Evaluations: A Case Report.

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Cureus 📖 저널 OA 99.9% 2021: 42/43 OA 2022: 79/79 OA 2023: 181/181 OA 2024: 284/284 OA 2025: 774/774 OA 2026: 506/506 OA 2021~2026 2026 Vol.18(2) p. e104199 OA
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Foster JR, Murray M

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Laugier-Hunziker syndrome (LHS) is a rare, benign acquired pigmentary disorder characterized by mucosal macules that can resemble more serious systemic disease.

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APA Foster JR, Murray M (2026). Laugier-Hunziker Syndrome Diagnosed by a Medical Student After Multiple Failed Specialist Evaluations: A Case Report.. Cureus, 18(2), e104199. https://doi.org/10.7759/cureus.104199
MLA Foster JR, et al.. "Laugier-Hunziker Syndrome Diagnosed by a Medical Student After Multiple Failed Specialist Evaluations: A Case Report.." Cureus, vol. 18, no. 2, 2026, pp. e104199.
PMID 41909421 ↗

Abstract

Laugier-Hunziker syndrome (LHS) is a rare, benign acquired pigmentary disorder characterized by mucosal macules that can resemble more serious systemic disease. We describe an 82-year-old woman with a four-year history of progressive oral hyperpigmentation involving the lower lip, buccal mucosa, and gingiva, with sparing of the tongue and upper lip, in whom repeated specialist evaluations had not yielded a diagnosis. A comprehensive clinical assessment in a family medicine clinic, including review of prior negative systemic workups, led a third-year medical student to recognize the pattern as LHS. The patient also reported similar pigmentary changes in her mother around the time of a lymphoma diagnosis, raising the possibility of familial or environmental influences, although no causal association could be established. This unusually late-onset presentation underscores the need to consider LHS in elderly patients with unexplained oral pigmentation and highlights the value of attentive history-taking and examination in primary care.

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