Adult T-cell Leukemia Following Satralizumab Treatment for Neuromyelitis Optica Spectrum Disorder.
1/5 보강
A 78-year-old woman with aquaporin 4 antibody-positive neuromyelitis optica spectrum disorder (NMOSD) developed acute-type adult T-cell leukemia (ATL) 1 month after initiating satralizumab, without pr
APA
Sakurai K, Ashikawa Y, et al. (2026). Adult T-cell Leukemia Following Satralizumab Treatment for Neuromyelitis Optica Spectrum Disorder.. Internal medicine (Tokyo, Japan), 65(5), 732-736. https://doi.org/10.2169/internalmedicine.5938-25
MLA
Sakurai K, et al.. "Adult T-cell Leukemia Following Satralizumab Treatment for Neuromyelitis Optica Spectrum Disorder.." Internal medicine (Tokyo, Japan), vol. 65, no. 5, 2026, pp. 732-736.
PMID
40738679 ↗
Abstract 한글 요약
A 78-year-old woman with aquaporin 4 antibody-positive neuromyelitis optica spectrum disorder (NMOSD) developed acute-type adult T-cell leukemia (ATL) 1 month after initiating satralizumab, without prior human T-cell leukemia virus type 1 screening. She presented with respiratory symptoms and hematochezia after receiving three doses. Laboratory tests revealed abnormal lymphocytosis and HTLV-1 positivity, with monoclonal proliferation. Despite CHOP chemotherapy, the patient died within two weeks of treatment initiation. interleukin-6 inhibition may impair the host defense against HTLV-1 oncogenesis. This case highlights the potential risk of ATL following treatment with satralizumab, especially in HTLV-1 endemic areas, and the importance of HTLV-1 screening and clonality assessment before treatment in patients with NMOSD.
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