Genomic analysis of coexisting β-lactamase plasmids in Klebsiella pneumoniae from an immunocompromised patient.
1/5 보강
PICO 자동 추출 (휴리스틱, conf 2/4)
유사 논문P · Population 대상 환자/모집단
환자: acute myeloblastic leukemia (AML) in Jazan region, Saudi Arabia
I · Intervention 중재 / 시술
추출되지 않음
C · Comparison 대조 / 비교
추출되지 않음
O · Outcome 결과 / 결론
pneumoniae clone carrying extensive resistance and virulence determinants on multiple plasmids, including bla and bla. Its plasmids similarity to geographically distant strains underscore global AMR circulation, emphasizing the need for enhanced surveillance of ST147 CRKP isolates in high-risk populations.
[OBJECTIVE] Infection significantly increases morbidity and mortality in hematologic malignancies due to immunosuppression, multiple risk factors, and greater susceptibility to healthcare-associated i
APA
Brek TM, Alshafie HA, et al. (2026). Genomic analysis of coexisting β-lactamase plasmids in Klebsiella pneumoniae from an immunocompromised patient.. Journal of global antimicrobial resistance, 47, 73-78. https://doi.org/10.1016/j.jgar.2026.02.002
MLA
Brek TM, et al.. "Genomic analysis of coexisting β-lactamase plasmids in Klebsiella pneumoniae from an immunocompromised patient.." Journal of global antimicrobial resistance, vol. 47, 2026, pp. 73-78.
PMID
41662989 ↗
Abstract 한글 요약
[OBJECTIVE] Infection significantly increases morbidity and mortality in hematologic malignancies due to immunosuppression, multiple risk factors, and greater susceptibility to healthcare-associated infections. We conducted a comprehensive genomic analysis of ESBL and carbapenemase co-producing K. pneumoniae (KP-JZ177) isolate recovered from a vulnerable patient with acute myeloblastic leukemia (AML) in Jazan region, Saudi Arabia.
[METHODS] A clinical K. pneumoniae (KP-JZ177) isolate was obtained from a wound swab of a female patient with AML in the Hematology-Oncology unit of a tertiary hospital in Jazan region. Identification and AST were performed using the MicroScan WalkAway system. Whole-genome sequencing enabled comprehensive characterization of the strain's genetic profile, resistance determinants, virulence factors, and plasmid replicons.
[RESULTS] KP-JZ177 isolate displayed resistance to all tested antimicrobials except amikacin, gentamicin, tigecycline, and colistin. The genomic features of KP-JZ177 indicate substantial adaptability and pathogenic potential. KP-JZ177 belongs to sequence type ST147, a globally recognized high-risk clone associated with carbapenem resistance and recurrent hospital outbreaks. Its extensive drug-resistant (XDR) profile is driven by the co-occurrence of carbapenemase genes bla and bla, which together confer high-level β-lactam resistance. Serotyping classified the isolate as KL64 with an O1/O2v1 O-antigen. Genomic analysis also revealed eight plasmids, many carried β-lactamase determinants and several mobile genetic elements (MGEs).
[CONCLUSIONS] Genomic profiling of KP-JZ177 reveals high-risk K. pneumoniae clone carrying extensive resistance and virulence determinants on multiple plasmids, including bla and bla. Its plasmids similarity to geographically distant strains underscore global AMR circulation, emphasizing the need for enhanced surveillance of ST147 CRKP isolates in high-risk populations.
[METHODS] A clinical K. pneumoniae (KP-JZ177) isolate was obtained from a wound swab of a female patient with AML in the Hematology-Oncology unit of a tertiary hospital in Jazan region. Identification and AST were performed using the MicroScan WalkAway system. Whole-genome sequencing enabled comprehensive characterization of the strain's genetic profile, resistance determinants, virulence factors, and plasmid replicons.
[RESULTS] KP-JZ177 isolate displayed resistance to all tested antimicrobials except amikacin, gentamicin, tigecycline, and colistin. The genomic features of KP-JZ177 indicate substantial adaptability and pathogenic potential. KP-JZ177 belongs to sequence type ST147, a globally recognized high-risk clone associated with carbapenem resistance and recurrent hospital outbreaks. Its extensive drug-resistant (XDR) profile is driven by the co-occurrence of carbapenemase genes bla and bla, which together confer high-level β-lactam resistance. Serotyping classified the isolate as KL64 with an O1/O2v1 O-antigen. Genomic analysis also revealed eight plasmids, many carried β-lactamase determinants and several mobile genetic elements (MGEs).
[CONCLUSIONS] Genomic profiling of KP-JZ177 reveals high-risk K. pneumoniae clone carrying extensive resistance and virulence determinants on multiple plasmids, including bla and bla. Its plasmids similarity to geographically distant strains underscore global AMR circulation, emphasizing the need for enhanced surveillance of ST147 CRKP isolates in high-risk populations.
🏷️ 키워드 / MeSH 📖 같은 키워드 OA만
- Humans
- beta-Lactamases
- Klebsiella pneumoniae
- Plasmids
- Female
- Immunocompromised Host
- Klebsiella Infections
- Anti-Bacterial Agents
- Whole Genome Sequencing
- Microbial Sensitivity Tests
- Drug Resistance
- Multiple
- Bacterial
- Leukemia
- Myeloid
- Acute
- Genome
- Saudi Arabia
- Virulence Factors
- Genomics
- Bacterial Proteins
- Carbapenem-resistant
- High-risk clone
- K. pneumoniae st147
… 외 2개
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