Predictors of Differentiation Syndrome in Patients with Acute Promyelocytic Leukemia Following Induction Therapy: A Meta-Analysis.
메타분석
1/5 보강
[UNLABELLED] Differentiation syndrome (DS) is a life-threatening condition caused by the use of differentiating agents, which are used for remission induction in acute promyelocytic leukemia (APL).Thi
- 95% CI 2.06 to 7.25
- OR 3.87
- 연구 설계 meta-analysis
APA
Alghwyeen W, Mohamed SF, et al. (2026). Predictors of Differentiation Syndrome in Patients with Acute Promyelocytic Leukemia Following Induction Therapy: A Meta-Analysis.. Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion, 42(2), 406-415. https://doi.org/10.1007/s12288-025-02036-5
MLA
Alghwyeen W, et al.. "Predictors of Differentiation Syndrome in Patients with Acute Promyelocytic Leukemia Following Induction Therapy: A Meta-Analysis.." Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion, vol. 42, no. 2, 2026, pp. 406-415.
PMID
41728172 ↗
Abstract 한글 요약
[UNLABELLED] Differentiation syndrome (DS) is a life-threatening condition caused by the use of differentiating agents, which are used for remission induction in acute promyelocytic leukemia (APL).This study aimed to investigate the current evidence on risk factors for DS. Related articles were searched from PubMed, Scopus, Cochrane Library, Web of Science, and China National Knowledge Infrastructure. RevMan 5.4 software was used for meta-analysis. A total of 22 studies were included in this study. Risk factors that had significant relation with DS were BMI > 25 Kg/m (OR: 3.87, 95% CI: 2.06 to 7.25, < 0.0001), WBCs > 10/L (OR: 3.02, 95% CI: 1.85 to 4.92, < 0.00001), and high risk APL (OR:2.16, 95% CI: 1.39 to 2.26, = 0.0007). This study highlights important predictive factors for DS, with WBCs > 10/L, high-risk APL and BMI > 25 Kg/m as the most prominent factors.
[SUPPLEMENTARY INFORMATION] The online version contains supplementary material available at 10.1007/s12288-025-02036-5.
[SUPPLEMENTARY INFORMATION] The online version contains supplementary material available at 10.1007/s12288-025-02036-5.
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