Reprogramming of stroma-derived chemokine networks drives the loss of tissue organization in nodal B cell lymphoma.
1/5 보강
Lymph node (LN) function requires the organization of cells into higher-order spatial units.
APA
Czernilofsky F, Mathioudaki A, et al. (2026). Reprogramming of stroma-derived chemokine networks drives the loss of tissue organization in nodal B cell lymphoma.. Nature cancer, 7(3), 538-552. https://doi.org/10.1038/s43018-026-01136-z
MLA
Czernilofsky F, et al.. "Reprogramming of stroma-derived chemokine networks drives the loss of tissue organization in nodal B cell lymphoma.." Nature cancer, vol. 7, no. 3, 2026, pp. 538-552.
PMID
41882179 ↗
Abstract 한글 요약
Lymph node (LN) function requires the organization of cells into higher-order spatial units. However, the principles governing LN architecture in health and disease remain poorly understood. Here, we used single-cell and spatial mapping to investigate the mechanisms directing immune cell organization in human LNs and its disruption in architecturally distinct lymphoma entities: indolent follicular lymphoma (FL) and aggressive diffuse large B cell lymphoma (DLBCL). Our data substantiate the central role of LN-resident stromal cells in chemokine-driven lymphocyte zonation and reveal an inflammatory feedback loop fueled by tumor-reactive T cells that triggers stromal remodeling, progressive loss of homeostatic chemokine gradients, and tissue disorganization from a non-malignant state to FL and DLBCL. Loss of homeostatic chemokines was associated with adverse patient survival, identifying the underlying architectural rearrangement as a key event during lymphomagenesis. Collectively, our results highlight the principles of LN organization and suggest how lymphoma-induced microenvironmental reprogramming drives the loss of tissue organization.
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