Long-term clinical outcomes of gastric mucosa-associated lymphoid tissue lymphoma: a retrospective study in regions with a high prevalence of Helicobacter pylori infection.
1/5 보강
PICO 자동 추출 (휴리스틱, conf 3/4)
유사 논문P · Population 대상 환자/모집단
398 patients were included, with a mean age at diagnosis of 55.
I · Intervention 중재 / 시술
eradication therapy (98
C · Comparison 대조 / 비교
추출되지 않음
O · Outcome 결과 / 결론
Accurate staging at diagnosis is essential for optimal management, as disease stage and the presence of lymphadenopathy are key predictors of relapse. [SUPPLEMENTARY INFORMATION] The online version contains supplementary material available at 10.1186/s12876-026-04699-4.
[BACKGROUND] This study aims to investigate the treatment outcomes and identify risk factors influencing complete remission (CR) and relapse in patients with gastric MALT lymphoma across different tre
- 95% CI 1.0–5.5
APA
Kim JW, Yeom DH, et al. (2026). Long-term clinical outcomes of gastric mucosa-associated lymphoid tissue lymphoma: a retrospective study in regions with a high prevalence of Helicobacter pylori infection.. BMC gastroenterology, 26(1). https://doi.org/10.1186/s12876-026-04699-4
MLA
Kim JW, et al.. "Long-term clinical outcomes of gastric mucosa-associated lymphoid tissue lymphoma: a retrospective study in regions with a high prevalence of Helicobacter pylori infection.." BMC gastroenterology, vol. 26, no. 1, 2026.
PMID
41776408 ↗
Abstract 한글 요약
[BACKGROUND] This study aims to investigate the treatment outcomes and identify risk factors influencing complete remission (CR) and relapse in patients with gastric MALT lymphoma across different treatment modalities.
[METHODS] Three-hundred and ninety-eight patients with gastric MALT lymphoma were followed up for at least 48 weeks over 15 years in five tertiary hospitals in regions with high prevalence of () infection. A retrospective review was performed using medical records.
[RESULTS] A total of 398 patients were included, with a mean age at diagnosis of 55.5 ± 12.2 years and 176 (44.2%) were male. infection was identified in 293 patients (73.6%), and 363 (91.2%) were diagnosed with stage IE. Significant differences in age, sex, and stage at diagnosis were observed between -positive (HPP) and negative groups (HPN, all < 0.05). In the HPP group, most patients underwent eradication therapy (98.9%), whereas 77.3% of HPN patients received eradication therapy, often combined with radiotherapy or chemotherapy. CR rate was 97.0%, with 98.3% in HPP and 93.3% in HPN ( = 0.018). During a median follow-up of 179 weeks, relapse occurred in 8.3% of patients, with 7.9% in HPP and 10.2% in HPN, respectively. Non-IE Modified Ann Arbor Stage (HR, 2.4; 95% CI, 1.0–5.5; = 0.044), presence of lymphadenopathy (HR, 1.9; 95% CI, 1.2–3.1; = 0.010), and lesions in multiple locations (HR, 2.1; 95% CI, 1.0 ~ 4.2; = 0.037) at diagnosis correlated with a higher cumulative incidence of relapse (CIR). Multivariate Cox regression analysis showed that Non-IE Modified Ann Arbor Stage (aHR, 1.9; 95% CI, 1.2‒2.9; = 0.004) and presence of lymphadenopathy (aHR, 1.5; 95% CI, 1.0‒2.3; = 0.037) remained significantly correlated with higher CIR.
[CONCLUSIONS] Patients with gastric MALT lymphoma generally have a favorable prognosis, and eradication can lead to CR, even in -negative MALT lymphoma cases. Accurate staging at diagnosis is essential for optimal management, as disease stage and the presence of lymphadenopathy are key predictors of relapse.
[SUPPLEMENTARY INFORMATION] The online version contains supplementary material available at 10.1186/s12876-026-04699-4.
[METHODS] Three-hundred and ninety-eight patients with gastric MALT lymphoma were followed up for at least 48 weeks over 15 years in five tertiary hospitals in regions with high prevalence of () infection. A retrospective review was performed using medical records.
[RESULTS] A total of 398 patients were included, with a mean age at diagnosis of 55.5 ± 12.2 years and 176 (44.2%) were male. infection was identified in 293 patients (73.6%), and 363 (91.2%) were diagnosed with stage IE. Significant differences in age, sex, and stage at diagnosis were observed between -positive (HPP) and negative groups (HPN, all < 0.05). In the HPP group, most patients underwent eradication therapy (98.9%), whereas 77.3% of HPN patients received eradication therapy, often combined with radiotherapy or chemotherapy. CR rate was 97.0%, with 98.3% in HPP and 93.3% in HPN ( = 0.018). During a median follow-up of 179 weeks, relapse occurred in 8.3% of patients, with 7.9% in HPP and 10.2% in HPN, respectively. Non-IE Modified Ann Arbor Stage (HR, 2.4; 95% CI, 1.0–5.5; = 0.044), presence of lymphadenopathy (HR, 1.9; 95% CI, 1.2–3.1; = 0.010), and lesions in multiple locations (HR, 2.1; 95% CI, 1.0 ~ 4.2; = 0.037) at diagnosis correlated with a higher cumulative incidence of relapse (CIR). Multivariate Cox regression analysis showed that Non-IE Modified Ann Arbor Stage (aHR, 1.9; 95% CI, 1.2‒2.9; = 0.004) and presence of lymphadenopathy (aHR, 1.5; 95% CI, 1.0‒2.3; = 0.037) remained significantly correlated with higher CIR.
[CONCLUSIONS] Patients with gastric MALT lymphoma generally have a favorable prognosis, and eradication can lead to CR, even in -negative MALT lymphoma cases. Accurate staging at diagnosis is essential for optimal management, as disease stage and the presence of lymphadenopathy are key predictors of relapse.
[SUPPLEMENTARY INFORMATION] The online version contains supplementary material available at 10.1186/s12876-026-04699-4.
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