Analysis of risk factors for infusion-related reactions in patients with B-cell lymphoma during obinutuzumab treatment.
1/5 보강
PICO 자동 추출 (휴리스틱, conf 3/4)
유사 논문P · Population 대상 환자/모집단
100 patients (48 men, 52 women) with a mean age of 55.
I · Intervention 중재 / 시술
obinutuzumab
C · Comparison 대조 / 비교
추출되지 않음
O · Outcome 결과 / 결론
Multivariate analysis identified splenomegaly and pre-treatment LDH levels as IRR risk factors. This research assists in predicting IRRs to improve patient outcomes.
This study investigated the risk factors associated with infusion-related reactions (IRRs) in B-cell lymphoma patients receiving obinutuzumab.
- p-value P < 0.05
APA
Wang Z, Zhang Y, et al. (2026). Analysis of risk factors for infusion-related reactions in patients with B-cell lymphoma during obinutuzumab treatment.. Journal of chemotherapy (Florence, Italy), 1-10. https://doi.org/10.1080/1120009X.2026.2640329
MLA
Wang Z, et al.. "Analysis of risk factors for infusion-related reactions in patients with B-cell lymphoma during obinutuzumab treatment.." Journal of chemotherapy (Florence, Italy), 2026, pp. 1-10.
PMID
41804192 ↗
Abstract 한글 요약
This study investigated the risk factors associated with infusion-related reactions (IRRs) in B-cell lymphoma patients receiving obinutuzumab. A retrospective analysis of Peking Union Medical College Hospital patients (January 2021-December 2024) was conducted to examine factors between patients experiencing IRRs ( = 44) and those without ( = 56). Parameters included gender, age, histological subtype, treatment status, Ann Arbor staging, extranodal/bone marrow involvement, bulky disease, splenomegaly status, serum lactate dehydrogenase (LDH), beta-2 microglobulin (βMG) concentrations, and lymphocyte count. 100 patients (48 men, 52 women) with a mean age of 55.7 years (range: 44-67) received obinutuzumab. Univariate analyses showed higher prevalence of bone marrow involvement and splenomegaly in the IRR group. Median LDH (235 195) and βMG (4 vs. 3) levels pre-treatment were significantly elevated in the IRR group (P < 0.05). Multivariate analysis identified splenomegaly and pre-treatment LDH levels as IRR risk factors. This research assists in predicting IRRs to improve patient outcomes.
🏷️ 키워드 / MeSH 📖 같은 키워드 OA만
같은 제1저자의 인용 많은 논문 (5)
- Flap perfusion assessment with indocyanine green angiography in deep inferior epigastric perforator flap breast reconstruction: A systematic review and meta-analysis.
- A case of pulmonary mucosa-associated lymphoid tissue lymphoma with plasmacytic differentiation and amyloid deposition: case report and literature review.
- Role of ferroptosis and autophagy in pulmonary diseases.
- NUP62 Elevates USP10 Expression and Promotes Tamoxifen Resistance of Breast Cancer by Deubiquitinating ERα.
- Multi-omics analysis identifies a glycosyltransferase-related prognostic signature linked to the immune landscape in colorectal cancer.
🏷️ 같은 키워드 · 무료전문 — 이 논문 MeSH/keyword 기반
- A novel real-world data methodology for lymphoma outcome classification: the real-world Lugano study.
- Case Report: Secondary neurolymphomatosis successfully treated with sequential Bruton's tyrosine kinase inhibitor and bispecific antibody therapy.
- Breast Implant-Associated Epstein-Barr Virus-Positive Diffuse Large B-Cell Lymphoma.
- Prognostic Value of the CALLY Index in Diffuse Large B-Cell Lymphoma: Linking Inflammation, Nutrition, and Tumor Biology.
- Longitudinal Whole-Exome Sequencing Identifies Clonal Hematopoiesis and Genomic Heterogeneity as a Predictor of Treatment Outcome in Patients with Newly Diagnosed, Elderly Chronic Lymphocytic Leukemia.
- Survival outcomes and treatment patterns in primary vertebral diffuse large B-cell lymphoma.