Successful Outcome of Acute Promyelocytic Leukemia Complicated by Bone Marrow Necrosis and Posterior Reversible Encephalopathy Syndrome, During Treatment With an All-Trans Retinoic Acid Plus Arsenic Trioxide-Based Regimen.
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Acute promyelocytic leukemia (APL) is a distinct subtype of acute myeloid leukemia characterized by the fusion gene and frequent coagulopathy.
APA
Venou TM, Mainou M, et al. (2026). Successful Outcome of Acute Promyelocytic Leukemia Complicated by Bone Marrow Necrosis and Posterior Reversible Encephalopathy Syndrome, During Treatment With an All-Trans Retinoic Acid Plus Arsenic Trioxide-Based Regimen.. Cureus, 18(3), e104972. https://doi.org/10.7759/cureus.104972
MLA
Venou TM, et al.. "Successful Outcome of Acute Promyelocytic Leukemia Complicated by Bone Marrow Necrosis and Posterior Reversible Encephalopathy Syndrome, During Treatment With an All-Trans Retinoic Acid Plus Arsenic Trioxide-Based Regimen.." Cureus, vol. 18, no. 3, 2026, pp. e104972.
PMID
41970134 ↗
Abstract 한글 요약
Acute promyelocytic leukemia (APL) is a distinct subtype of acute myeloid leukemia characterized by the fusion gene and frequent coagulopathy. All-trans retinoic acid (ATRA) plus arsenic trioxide (ATO)-based regimens achieve excellent complete remission rates exceeding 95% with durable molecular responses. However, treatment-related and disease-related complications may occur during therapy. We report a case of a 57-year-old man with APL complicated by bone marrow necrosis, pulmonary complications, and posterior reversible encephalopathy syndrome. Multidisciplinary supportive care with continuation of ATRA-ATO therapy resulted in complete hematologic and molecular remission. This case highlights the importance of recognizing and managing complex complications in APL while maintaining curative therapy.
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