Prevalence and Risk Factors of Acute Pancreatitis in Childhood Acute Leukemia.
1/5 보강
PICO 자동 추출 (휴리스틱, conf 3/4)
유사 논문P · Population 대상 환자/모집단
618 patients with leukemia, 70 children with abdominal pain were identified, and 17 were diagnosed with AP.
I · Intervention 중재 / 시술
high- to very-high-risk treatment protocols (76
C · Comparison 대조 / 비교
추출되지 않음
O · Outcome 결과 / 결론
Careful monitoring of L-asparaginase dosing may be required. Larger studies are needed to better identify the risk factors and preventive strategies.
[BACKGROUND/OBJECTIVES] Acute pancreatitis (AP) is an uncommon but serious complication in children undergoing treatment for acute leukemia.
APA
Thepuatrakul K, Chanpong A, et al. (2026). Prevalence and Risk Factors of Acute Pancreatitis in Childhood Acute Leukemia.. Cancers, 18(6). https://doi.org/10.3390/cancers18060910
MLA
Thepuatrakul K, et al.. "Prevalence and Risk Factors of Acute Pancreatitis in Childhood Acute Leukemia.." Cancers, vol. 18, no. 6, 2026.
PMID
41899516
Abstract
[BACKGROUND/OBJECTIVES] Acute pancreatitis (AP) is an uncommon but serious complication in children undergoing treatment for acute leukemia. We aimed to determine the prevalence of AP in pediatric patients with acute leukemia, identify its risk factors, and evaluate their impact on treatment outcomes and overall survival.
[MATERIALS AND METHODS] We retrospectively reviewed the medical records of children with acute leukemia who developed acute abdominal pain suggestive of AP at Songklanagarind Hospital between 2004 and 2024. Demographic data, including leukemia subtypes, treatment protocols, and clinical outcomes, were compared between the patients with and without AP.
[RESULTS] Of the 618 patients with leukemia, 70 children with abdominal pain were identified, and 17 were diagnosed with AP. The prevalence of AP was 2.8%. Most children with acute leukemia and AP had T-cell subtypes (50.0%) and received high- to very-high-risk treatment protocols (76.5%). Patients with AP experienced a shorter duration of abdominal pain before diagnosis and required imaging more frequently than the non-AP patients did (100% vs. 56.6%). They required a prolonged fasting period and greater intravenous fluid volume within 48 h. The overall mortality rate (all-cause during follow-up) was significantly higher in the AP group. Using high- to very-high-risk chemotherapy protocols was a risk factor for AP, and the accumulative L-asparaginase dose of ≥55,200 IU/m could increase AP risk.
[CONCLUSIONS] AP is significantly associated with increased overall mortality in children with acute leukemia. Careful monitoring of L-asparaginase dosing may be required. Larger studies are needed to better identify the risk factors and preventive strategies.
[MATERIALS AND METHODS] We retrospectively reviewed the medical records of children with acute leukemia who developed acute abdominal pain suggestive of AP at Songklanagarind Hospital between 2004 and 2024. Demographic data, including leukemia subtypes, treatment protocols, and clinical outcomes, were compared between the patients with and without AP.
[RESULTS] Of the 618 patients with leukemia, 70 children with abdominal pain were identified, and 17 were diagnosed with AP. The prevalence of AP was 2.8%. Most children with acute leukemia and AP had T-cell subtypes (50.0%) and received high- to very-high-risk treatment protocols (76.5%). Patients with AP experienced a shorter duration of abdominal pain before diagnosis and required imaging more frequently than the non-AP patients did (100% vs. 56.6%). They required a prolonged fasting period and greater intravenous fluid volume within 48 h. The overall mortality rate (all-cause during follow-up) was significantly higher in the AP group. Using high- to very-high-risk chemotherapy protocols was a risk factor for AP, and the accumulative L-asparaginase dose of ≥55,200 IU/m could increase AP risk.
[CONCLUSIONS] AP is significantly associated with increased overall mortality in children with acute leukemia. Careful monitoring of L-asparaginase dosing may be required. Larger studies are needed to better identify the risk factors and preventive strategies.