Novel Marine Fungus-Derived Mycophenolic Acids That Inhibit Acute Myeloid Leukemia Cell Proliferation.
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PICO 자동 추출 (휴리스틱, conf 2/4)
유사 논문P · Population 대상 환자/모집단
Eight of these compounds were evaluated for anti-proliferative effects against nine human cancer cell lines and the IC values ranged from nM to μM levels.
I · Intervention 중재 / 시술
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C · Comparison 대조 / 비교
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O · Outcome 결과 / 결론
Eight of these compounds were evaluated for anti-proliferative effects against nine human cancer cell lines and the IC values ranged from nM to μM levels. Compounds , - showed potent inhibition activity against MOLM-13 acute myeloid leukemia cells with IC values between 0.13 and 1.13 μM.
Nine new mycophenolic acid derivatives, penicacids O-W (-), two first-time reported natural products (, ), and five known compounds (-), were isolated from a marine-derived fungus RCDB005 found in a
APA
Deng G, Ruan W, et al. (2026). Novel Marine Fungus-Derived Mycophenolic Acids That Inhibit Acute Myeloid Leukemia Cell Proliferation.. Marine drugs, 24(3). https://doi.org/10.3390/md24030108
MLA
Deng G, et al.. "Novel Marine Fungus-Derived Mycophenolic Acids That Inhibit Acute Myeloid Leukemia Cell Proliferation.." Marine drugs, vol. 24, no. 3, 2026.
PMID
41892967
Abstract
Nine new mycophenolic acid derivatives, penicacids O-W (-), two first-time reported natural products (, ), and five known compounds (-), were isolated from a marine-derived fungus RCDB005 found in a South China Sea sediment sample. Their structures were determined using NMR, HRESIMS, and optical rotatory dispersion (ORD) spectra, electronic circular dichroism (ECD) calculations, X-ray crystallography, and modified Mosher's methods. Eight of these compounds were evaluated for anti-proliferative effects against nine human cancer cell lines and the IC values ranged from nM to μM levels. Compounds , - showed potent inhibition activity against MOLM-13 acute myeloid leukemia cells with IC values between 0.13 and 1.13 μM.
MeSH Terms
Humans; Cell Proliferation; Cell Line, Tumor; Leukemia, Myeloid, Acute; Mycophenolic Acid; Penicillium; Antineoplastic Agents; Aquatic Organisms; China; Inhibitory Concentration 50; Molecular Structure; Drug Screening Assays, Antitumor; Geologic Sediments
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