Integrative CSF profiling identifies disease-specific immune responses in leptomeningeal disease.
1/5 보강
PICO 자동 추출 (휴리스틱, conf 2/4)
유사 논문P · Population 대상 환자/모집단
환자: CNS lymphoma (CNSL), brain metastases (BrMs), and glioblastoma (GB), alongside deep TCR sequencing of blood and spatial transcriptomics of brain lesions
I · Intervention 중재 / 시술
추출되지 않음
C · Comparison 대조 / 비교
추출되지 않음
O · Outcome 결과 / 결론
Longitudinal sampling reveals dynamic immune changes and emerging resistant clones. These findings establish the CSF as an immune-active compartment reflecting disease-specific features and highlight the value of CSF liquid biopsy for immune monitoring and therapeutic stratification in LMD.
Leptomeningeal disease (LMD) is a devastating manifestation of advanced cancer, marked by rapid neurological decline and limited treatment options.
APA
Nieto P, Klinsing S, et al. (2026). Integrative CSF profiling identifies disease-specific immune responses in leptomeningeal disease.. Cell reports. Medicine, 7(3), 102651. https://doi.org/10.1016/j.xcrm.2026.102651
MLA
Nieto P, et al.. "Integrative CSF profiling identifies disease-specific immune responses in leptomeningeal disease.." Cell reports. Medicine, vol. 7, no. 3, 2026, pp. 102651.
PMID
41794040 ↗
Abstract 한글 요약
Leptomeningeal disease (LMD) is a devastating manifestation of advanced cancer, marked by rapid neurological decline and limited treatment options. Immune profiling in central nervous system (CNS) neoplasms, including LMD, is critical for understanding disease biology and guiding therapy. Here, we use single-cell RNA and T cell receptor (TCR) sequencing of cerebrospinal fluid (CSF) from patients with CNS lymphoma (CNSL), brain metastases (BrMs), and glioblastoma (GB), alongside deep TCR sequencing of blood and spatial transcriptomics of brain lesions. We uncover distinct, disease-specific CSF immune landscapes: CNSL-associated LMD shows clonal T cell expansion, while BrMs and GB are enriched in blood-derived and resident-like myeloid cells. Spatial analysis confirms transcriptional similarities between CSF and tumor microenvironments. Longitudinal sampling reveals dynamic immune changes and emerging resistant clones. These findings establish the CSF as an immune-active compartment reflecting disease-specific features and highlight the value of CSF liquid biopsy for immune monitoring and therapeutic stratification in LMD.
🏷️ 키워드 / MeSH 📖 같은 키워드 OA만
- Humans
- Meningeal Neoplasms
- Tumor Microenvironment
- Male
- Female
- Middle Aged
- Receptors
- Antigen
- T-Cell
- Brain Neoplasms
- Aged
- Glioblastoma
- Transcriptome
- CNS lymphoma
- T cell receptor sequencing
- brain metastasi
- cerebrospinal fluid
- glioblastoma
- leptomeningeal disease
- liquid biopsy
- single-cell RNA sequencing
- tumor immune microenvironment
🏷️ 같은 키워드 · 무료전문 — 이 논문 MeSH/keyword 기반
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