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Defying the odds: A rare case of primary breast double-hit lymphoma with remarkable remission.

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SAGE open medical case reports 📖 저널 OA 100% 2021: 3/3 OA 2022: 2/2 OA 2023: 3/3 OA 2024: 5/5 OA 2025: 6/6 OA 2026: 9/9 OA 2021~2026 2026 Vol.14() p. 2050313X261417125 OA
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Alsaket LZ, Elkourashy SA, Kolleri J, Alobadli AM

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Malignant lymphoma in the breast is rare, with primary breast lymphoma and secondary breast lymphoma being the two subtypes.

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APA Alsaket LZ, Elkourashy SA, et al. (2026). Defying the odds: A rare case of primary breast double-hit lymphoma with remarkable remission.. SAGE open medical case reports, 14, 2050313X261417125. https://doi.org/10.1177/2050313X261417125
MLA Alsaket LZ, et al.. "Defying the odds: A rare case of primary breast double-hit lymphoma with remarkable remission.." SAGE open medical case reports, vol. 14, 2026, pp. 2050313X261417125.
PMID 41884745 ↗

Abstract

Malignant lymphoma in the breast is rare, with primary breast lymphoma and secondary breast lymphoma being the two subtypes. Primary breast lymphoma presents as a fast-growing, painless, palpable mass and is less frequent due to limited lymphoid tissue in the breast. Primary breast double-hit lymphoma is a very rare, highly aggressive malignancy that presents a great challenge regarding proper diagnosis and optimal treatment. Our case involved high-grade B-cell lymphoma with MYC and BCL2 rearrangement (double hit), treated with dose-adjusted etoposide, prednisone, vincristine, cyclophosphamide, and doxorubicin chemotherapy, resulting in complete resolution.

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