Diagnostic and treatment challenges associated with the atypical presentation of ALK-positive anaplastic large cell lymphoma in a Jehovah's Witness patient.
2/5 보강
TL;DR
This case underscores the importance of a broad differential diagnosis, judicious use of advanced diagnostics and individualised treatment planning, particularly in rare and aggressive lymphoproliferative disorders, particularly in rare and aggressive lymphoproliferative disorders.
OpenAlex 토픽 ·
Lymphoma Diagnosis and Treatment
Viral-associated cancers and disorders
Chronic Lymphocytic Leukemia Research
This case underscores the importance of a broad differential diagnosis, judicious use of advanced diagnostics and individualised treatment planning, particularly in rare and aggressive lymphoprolifera
APA
Debolina Pramanik, Bernardo Henrique Mendes Correa, et al. (2026). Diagnostic and treatment challenges associated with the atypical presentation of ALK-positive anaplastic large cell lymphoma in a Jehovah's Witness patient.. BMJ case reports, 19(3). https://doi.org/10.1136/bcr-2025-267859
MLA
Debolina Pramanik, et al.. "Diagnostic and treatment challenges associated with the atypical presentation of ALK-positive anaplastic large cell lymphoma in a Jehovah's Witness patient.." BMJ case reports, vol. 19, no. 3, 2026.
PMID
41871898 ↗
Abstract 한글 요약
A male in his 50s presented with profound leucocytosis, systemic symptoms and marked hepatosplenomegaly. Initial workup with peripheral blood flow cytometry suggested T-cell prolymphocytic leukaemia as the most likely diagnosis. However, bone marrow biopsy with comprehensive immunogenetic testing ultimately identified anaplastic lymphoma kinase-positive anaplastic large cell lymphoma in its leukemic phase. The treatment course was with targeted agents with less immunosuppressive risk, after taking into consideration that he was a Jehovah's Witness, who would not be able to receive blood products. Despite a transient response, the disease progressed rapidly. This case underscores the importance of a broad differential diagnosis, judicious use of advanced diagnostics and individualised treatment planning, particularly in rare and aggressive lymphoproliferative disorders.
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