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Leukemia cutis and all-trans retinoic acid-induced myocarditis in acute promyelocytic leukemia.

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Clinical hematology international 2026 Vol.8(1) p. 60-64
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Rahbari KJ, Patel PC, Profitt S, Kelley JT, O'Connell KA, Dewan AK, Kennedy KE, Mittlebeeler EE, Kishtagari A, Ball S, Mohan SR, Fedorov K

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Acute promyelocytic leukemia (APL) is frequently curable in the modern era using the chemotherapy-free regimen of all-trans retinoic acid (ATRA) and arsenic trioxide (ATO).

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APA Rahbari KJ, Patel PC, et al. (2026). Leukemia cutis and all-trans retinoic acid-induced myocarditis in acute promyelocytic leukemia.. Clinical hematology international, 8(1), 60-64. https://doi.org/10.46989/001c.158170
MLA Rahbari KJ, et al.. "Leukemia cutis and all-trans retinoic acid-induced myocarditis in acute promyelocytic leukemia.." Clinical hematology international, vol. 8, no. 1, 2026, pp. 60-64.
PMID 41907769 ↗

Abstract

Acute promyelocytic leukemia (APL) is frequently curable in the modern era using the chemotherapy-free regimen of all-trans retinoic acid (ATRA) and arsenic trioxide (ATO). However, rare disease manifestations and treatment complications may threaten these outcomes by requiring intensification or abbreviation of therapy. We present a unique case of a 36-year-old male with newly diagnosed low-risk APL with biopsy-confirmed leukemia cutis and isolated ATRA-associated myocarditis during induction therapy. Both APL leukemia cutis and ATRA-associated myocarditis are exceedingly rare, with each having less than 50 published cases to date. This report offers a comprehensive review of the literature, underscoring the importance of a comprehensive diagnostic evaluation and individualized care to ensure outstanding long-term outcomes for patients with APL.

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