Early Detection of Cell Death Using Transmembrane Water Exchange Magnetic Resonance Imaging.
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TL;DR
MAX measurements detect the onset of cell death in vivo earlier than diffusion‐weighted MRI (DWI) and in vitro with similar sensitivity as flow cytometry, demonstrating clinical translatability of the method.
OpenAlex 토픽 ·
Advanced MRI Techniques and Applications
Lipid Membrane Structure and Behavior
MRI in cancer diagnosis
MAX measurements detect the onset of cell death in vivo earlier than diffusion‐weighted MRI (DWI) and in vitro with similar sensitivity as flow cytometry, demonstrating clinical translatability of the
APA
Athanasia Kaika, Luca Nagel, et al. (2026). Early Detection of Cell Death Using Transmembrane Water Exchange Magnetic Resonance Imaging.. Advanced science (Weinheim, Baden-Wurttemberg, Germany), 13(23), e13317. https://doi.org/10.1002/advs.202513317
MLA
Athanasia Kaika, et al.. "Early Detection of Cell Death Using Transmembrane Water Exchange Magnetic Resonance Imaging.." Advanced science (Weinheim, Baden-Wurttemberg, Germany), vol. 13, no. 23, 2026, pp. e13317.
PMID
41405452 ↗
Abstract 한글 요약
Cell death plays a key role in cancer progression and treatment. After its onset, cell membrane integrity is often compromised. Here, it is shown in cells, animals and humans that the transmembrane water exchange rate, measured using magnetic resonance filter-exchange spectroscopy (FEXSY) or imaging (FEXI), and quantified by the apparent exchange rate (AXR), is an early biomarker of cell death. AXR measurements detect the onset of cell death in vivo earlier than diffusion-weighted MRI (DWI) and in vitro with similar sensitivity as flow cytometry. C magnetic resonance imaging (MRI) measurements of the malate/fumarate ratio (MFR), following injection of hyperpolarized [1,4-C]fumarate, in tumors displaying diffuse necrosis, are correlated with AXR. AXR detects early treatment response in colorectal and lymphoma tumor models while the apparent diffusion coefficient (ADC) measured by DWI remains unchanged. AXR measurements in human uterine fibroids show sensitivity to post-treatment changes soon after embolization, demonstrating clinical translatability of the method.
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