Identifying genes and pathways in familial lymphoid cancers using whole exome sequencing.
2/5 보강
TL;DR
It is hypothesized that there are shared susceptibility factors in families with these heterogenous lymphoid malignancies and identifying factors predisposing to different types of lymphoid cancers will help understand the etiology of these neoplasms.
OpenAlex 토픽 ·
Wnt/β-catenin signaling in development and cancer
Lymphoma Diagnosis and Treatment
Kruppel-like factors research
It is hypothesized that there are shared susceptibility factors in families with these heterogenous lymphoid malignancies and identifying factors predisposing to different types of lymphoid cancers wi
APA
Sneha Ralli, Samantha Jones, et al. (2026). Identifying genes and pathways in familial lymphoid cancers using whole exome sequencing.. Leukemia & lymphoma, 67(5), 1014-1028. https://doi.org/10.1080/10428194.2026.2624656
MLA
Sneha Ralli, et al.. "Identifying genes and pathways in familial lymphoid cancers using whole exome sequencing.." Leukemia & lymphoma, vol. 67, no. 5, 2026, pp. 1014-1028.
PMID
41652927 ↗
Abstract 한글 요약
Lymphoid cancers of different types and subtypes are known to cluster in families. We hypothesize that there are shared susceptibility factors in families with these heterogenous lymphoid malignancies. Exome sequencing was performed on 100 individuals from 43 lymphoid cancer pedigrees. Variants from 37 families were ranked using the eights-based vriant anking in edigrees (WARP) pipeline. Six affected unrelated probands were used for interpretation only. We detected recurrent variants in the germline lymphoid cancer gene in 4 (9%) of the 43 families, and variants in other genes involved in lymphoid cancers: and . Variants in genes including and involved in the WNT/β-catenin pathway were identified, representing a novel observation. Some variants appeared to segregate with specific types of lymphoid cancers; others were shared across different subtypes. Identifying factors predisposing to different types of lymphoid cancers will help understand the etiology of these neoplasms.
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