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Venetoclax and azacitidine versus CAG for unfit patients with newly diagnosed acute myeloid leukemia: A propensity score-matched analysis.

2/5 보강

Leukemia research 📖 저널 OA 12% 2023~2026 2026 Vol.163() p. 108187 Acute Myeloid Leukemia Research

TL;DR This study evaluated the clinical efficacy of venetoclax and azacitidine versus CAG for newly diagnosed adult acute myeloid leukemia (AML) unfit patients and showed a preference for VEN+AZA regarding OS, and patients with SRSF2 mutation favored CAG in OS.

PICO 자동 추출 (휴리스틱, conf 3/4)

유사 논문

P · Population 대상 환자/모집단

248 patients received VEN+AZA and 104 patients received CAG.

I · Intervention 중재 / 시술

VEN+AZA and 104 patients received CAG

C · Comparison 대조 / 비교

추출되지 않음

O · Outcome 결과 / 결론

31.7 % (P = 0.20). Patients with age ≥ 60 y (EFS, P = 0.032), ECOG≥ 2 (EFS, P = 0.047), secondary AML (OS, P = 0.015; EFS, P = 0.039), ELN intermediate-adverse karyotype (OS, P = 0.034; EFS, P = 0.044), RUNX1 mutation (OS, P = 0.003; EFS, P = 0.003) and IDH1/2 mutation (EFS, P = 0.039) showed a preference for VEN+AZA regarding OS, and patients with SRSF2 mutation favored CAG in OS (P = 0.031).

OpenAlex 토픽 · Acute Myeloid Leukemia Research Hematopoietic Stem Cell Transplantation Neutropenia and Cancer Infections

Chang G, Gao H, Wei Y, Fu Q, Jiang Q, Jiang H

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