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Enhancing tyrosine kinase inhibitor sensitivity by restoring IKAROS activity on GLUT1 expression and glycolysis in Philadelphia chromosome-positive acute lymphoblastic leukemia.

2/5 보강

Leukemia 📖 저널 OA 68.9% 2025~2026 2026 Vol.40(4) p. 794-805 OA Acute Lymphoblastic Leukemia researc

TL;DR It is found that Ph+ ALL cells with IKZF1 deletion are inherently resistant to TKIs, and the combination of TKIs with CX-4945 demonstrates the synergistic efficacy through restoring IKAROS transcriptional repression of GLUT1 and further suppressing glycolysis in Ph+ ALL.

PICO 자동 추출 (휴리스틱, conf 2/4)

유사 논문

P · Population 대상 환자/모집단

환자: Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL) are still less sensitive to tyrosine kinase inhibitors (TKIs)

I · Intervention 중재 / 시술

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C · Comparison 대조 / 비교

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O · Outcome 결과 / 결론

we found that Ph+ ALL cells with IKZF1 deletion are inherently resistant to TKIs.

OpenAlex 토픽 · Acute Lymphoblastic Leukemia research Chronic Myeloid Leukemia Treatments Protein Kinase Regulation and GTPase Signaling

Zhang L, Han Q, Xiang H, Lapalombella R, Eisfeld AK, Hanel WG

📖 무료 전문 🟢 PMC 전문 PMC13056559 🔓 OA PDF unpaywall · cc-by

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