Intravitreal foscarnet is an effective adjunct after systemic therapy failure in pediatric antiviral-resistant cytomegalovirus retinitis.
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OpenAlex 토픽 ·
Cytomegalovirus and herpesvirus research
Ocular Diseases and Behçet’s Syndrome
Legionella and Acanthamoeba research
This report describes the case of a school-aged male child with T-cell acute lymphoblastic leukemia who developed cytomegalovirus retinitis despite systemic antiviral therapy.
APA
Iden Amiri, Pooja Shah, et al. (2026). Intravitreal foscarnet is an effective adjunct after systemic therapy failure in pediatric antiviral-resistant cytomegalovirus retinitis.. The Journal of international medical research, 54(4), 3000605261436565. https://doi.org/10.1177/03000605261436565
MLA
Iden Amiri, et al.. "Intravitreal foscarnet is an effective adjunct after systemic therapy failure in pediatric antiviral-resistant cytomegalovirus retinitis.." The Journal of international medical research, vol. 54, no. 4, 2026, pp. 3000605261436565.
PMID
41986961 ↗
Abstract 한글 요약
This report describes the case of a school-aged male child with T-cell acute lymphoblastic leukemia who developed cytomegalovirus retinitis despite systemic antiviral therapy. The patient had a history of cytomegalovirus viremia that improved with intravenous foscarnet and oral maribavir; however, routine ophthalmic screening revealed new retinal whitening and hemorrhages in the right eye. Anterior chamber paracentesis confirmed intraocular cytomegalovirus DNA. Although systemic viral loads declined, the retinal lesions progressed toward the macula, prompting initiation of intravitreal foscarnet. Treatment was initiated with a 1.2 mg/0.05 mL injection under anesthesia, followed by 2.4 mg/0.1 mL injections administered twice weekly at the clinic. The regimen was well tolerated and resulted in stabilization and regression of retinitis without central involvement, with fundus photography demonstrating fading whitening and vascular sclerosis.This case highlights the importance of close ophthalmic monitoring in immunosuppressed pediatric patients with cytomegalovirus viremia and emphasizes intravitreal foscarnet as an effective adjunct when systemic therapy fails. Furthermore, it demonstrates the feasibility of administering multiple intravitreal injections in the pediatric population, underscoring the role of local antiviral delivery in preserving vision in cases of antiviral-resistant cytomegalovirus retinitis.
🏷️ 키워드 / MeSH 📖 같은 키워드 OA만
- Humans
- Male
- Foscarnet
- Antiviral Agents
- Cytomegalovirus Retinitis
- Intravitreal Injections
- Child
- Cytomegalovirus
- Drug Resistance
- Viral
- Cytomegalovirus retinitis
- UL97 mutation
- antiviral resistance
- intravitreal foscarnet
- leukemia-associated retinal infection
- pediatric ophthalmology
- retinal lesion progression
🏷️ 같은 키워드 · 무료전문 — 이 논문 MeSH/keyword 기반
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